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DC Chemicals Limited
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Product Name: Carnosine
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Dayang Chem (Hangzhou) Co., Ltd.
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305-84-0

305-84-0 structure

305-84-0 structure

Name: L-carnosine
Chemical Name: carnosine
CAS Number: 305-84-0
Molecular Formula: C₉H₁₄N₄O₃
Molecular Weight: 226.232
Catalog: Biochemical Peptide
Create Date: 2018-02-05 08:00:00
Modify Date: 2024-01-02 17:58:10
L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.

Name	carnosine
Synonyms	(2S)-2-(3-aminopropanamido)-3-(1H-imidazol-5-yl)propanoic acid N-b-Alanyl-L-histidine EINECS 206-169-9 L-Histidine, N-β-alanyl- β-Alanyl-L-histidine N-(b-Alanyl)-L-histidine N-β-Alanyl-L-histidin beta-Alanyl-L-histidine ignotine n-2-m L-IGNOTINE carnosine L-Histidine, N-(3-amino-1-hydroxypropylidene)-, (E)- karnozzn Carnosin L-Carnosine L-Histidine, β-alanyl- MFCD00005207 N-β-Alanyl-L-histidine (E)-N-(3-Amino-1-hydroxypropylidene)-L-histidine Karnozin H-β-Ala-His-OH

Description	L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.
Related Catalog	Research Areas >> Metabolic Disease Natural Products >> Others
Target	Human Endogenous Metabolite
In Vitro	L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging[1]. Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, and ROS and free radicals scavenging ability[2].
References	[1]. Hipkiss AR, et al. Would carnosine or a carnivorous diet help suppress aging and associated pathologies? Ann N Y Acad Sci. 2006 May;1067:369-74. [2]. Guney Y, et al. Carnosine may reduce lung injury caused by radiation therapy. Med Hypotheses. 2006;66(5):957-9.

Density	1.4±0.1 g/cm3
Boiling Point	656.2±55.0 °C at 760 mmHg
Melting Point	253 °C (dec.)(lit.)
Molecular Formula	C₉H₁₄N₄O₃
Molecular Weight	226.232
Flash Point	350.7±31.5 °C
Exact Mass	226.106583
PSA	121.10000
LogP	-2.17
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.591

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MS3080000

CHEMICAL NAME :: L-Histidine, N-beta-alanyl-

CAS REGISTRY NUMBER :: 305-84-0

BEILSTEIN REFERENCE NO. :: 0087671

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H14-N4-O3

MOLECULAR WEIGHT :: 226.27

WISWESSER LINE NOTATION :: T5M CNJ D1YVQMV2Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >14930 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4446149

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9087 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4446149 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 21 mg/kg

SEX/DURATION :: female 8-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,1219,1974

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	MS3080000
HS Code	2933290090

Precursor 7
34653-21-9 71-00-1 357409-05-3 378784-00-0
7440-44-0 7389-97-1 107-95-9
DownStream 2
71-00-1 107-95-9

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%