32421-46-8
32421-46-8 structure
- Name: Bunaftide
- Chemical Name: N-butyl-N-[2-(diethylamino)ethyl]naphthalene-1-carboxamide
- CAS Number: 32421-46-8
- Molecular Formula: C21H30N2O
- Molecular Weight: 326.47600
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-09-16 00:15:28
- Modify Date: 2024-01-02 21:51:14
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Bunaftide (Bunaftine; Bunaphtide; Meregon) is an antiarrhythmic agent.
| Name | N-butyl-N-[2-(diethylamino)ethyl]naphthalene-1-carboxamide |
|---|---|
| Synonyms |
EINECS 251-027-1
Bunaftina [INN-Spanish] Bunaphtide Bunaphtine Bunaftinum [INN-Latin] Bunaftine Bunaftine (INN) N-Butyl-N-(2-(diethylamino)ethyl)-1-naphthamide N-(2-Diethylaminoethyl)-N-n-butyl-1-naphthamid Bunaftide |
| Description | Bunaftide (Bunaftine; Bunaphtide; Meregon) is an antiarrhythmic agent. |
|---|---|
| Related Catalog | |
| In Vitro | At concentrations of 0.5-2.0 mM, Bunaftide causes contraction and rounding of the cells with loss of microvilli-like processes. Aggregates of dense, partly granular, partly fibrillar material form in the cytoplasm and the rough endoplasmic reticulum became vesiculated. Bundles of actin filaments are disrupted, forming rings, coils, and granules. 0.4 mM Bunaftide increases and 0.8-1.0 mM markedly decreases the percentage of mitotic cells, without accumulation of cells in any particular stage of mitosis. The drug may arrest the cell cycle at some point before mitosis; it may have a critical concentration above which the arrest becomes permanent[1]. Bunaftide at 1, 5 and 10 mg/L produces a concentration-dependent depression of the maximum rate of rise of the action potential in guinea pig papillary muscle preparations without affecting the resting membrane potential and the action potential amplitude. The action potential duration (APD50, APD90) is significantly prolonged by the treatment with 1 and 5 mg/L Bunaftide, while it is not changed by the treatment with 10 mg/L[2]. |
| Cell Assay | Human embryonic fibroblasts and HeLa cells are seeded into 35-mm plastic Petri dishes at a density of 1x105 cells/cm2. Bunaftide is used in final concentrations of 0.1-2.0 mM. The cells are exposed to the drug for periods ranging from 15 min to 24 h. To allow the cells to recover, the Bunaftide medium is removed and the cultures are left in standard medium for 4-24 h[1]. |
| References |
| Density | 1.026g/cm3 |
|---|---|
| Boiling Point | 476ºC at 760 mmHg |
| Molecular Formula | C21H30N2O |
| Molecular Weight | 326.47600 |
| Flash Point | 192ºC |
| Exact Mass | 326.23600 |
| PSA | 23.55000 |
| LogP | 4.42390 |
| Index of Refraction | 1.562 |
| Storage condition | 2-8℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2924299090 |
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| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |