581-31-7

581-31-7 structure

Name: Suberosin
Chemical Name: 7-methoxy-6-(3-methylbut-2-enyl)chromen-2-one
CAS Number: 581-31-7
Molecular Formula: C₁₅H₁₆O₃
Molecular Weight: 244.286
Catalog: Natural product Coumarin
Create Date: 2018-02-20 08:00:00
Modify Date: 2024-01-02 23:41:14
Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB[1][2].

Name	7-methoxy-6-(3-methylbut-2-enyl)chromen-2-one
Synonyms	2H-1-Benzopyran-2-one, 7-methoxy-6- (3-methyl-2-butenyl)- SUBEROSIN 7-Methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-2-one 7-Methoxy-6-(3-methyl-2-buten-1-yl)-2H-chromen-2-one 2H-1-Benzopyran-2-one, 7-methoxy-6-(3-methyl-2-buten-1-yl)- 2H-1-Benzopyran-2-one, 7-methoxy-6-(3-methyl-2-butenyl)- Coumarin, 7-methoxy-6- (3-methyl-2-butenyl)- 7-methoxy-6-prenylcoumarin Coumarin, 7-methoxy-6-(3-methyl-2-butenyl)-

Description	Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology
References	[1]. Y-C Chen, et al. Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-jB. British Journal of Pharmacology (2007) 150, 298-312. [2]. Golfakhrabadi F, et al. Anticoagulant activity of isolated coumarins (suberosin and suberenol) and toxicity evaluation of Ferulago carduchorum in rats. Pharm Biol. 2014 Oct;52(10):1335-40.

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