Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Saframycin A
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DC Chemicals Limited
China
Product Name: Saframycin A
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ShangHai DC Chemicals Co.,Ltd
China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Propanamide,N-[[(6S,7R,9R,14aS,15R)-7- cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-2,- 11-dimethoxy-3,12,16-trimethyl-1,4,10,13- tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]- benzazocin-9-yl]methyl]-2-oxo-
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66082-27-7

66082-27-7 structure

66082-27-7 structure

Name: Saframycin A
Chemical Name: (-)-saframycin A
CAS Number: 66082-27-7
Molecular Formula: C₂₉H₃₀N₄O₈
Molecular Weight: 562.57000
Create Date: 2016-05-24 03:50:22
Modify Date: 2024-04-02 15:00:53
A heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro.

Name	(-)-saframycin A

Density	1.44g/cm3
Molecular Formula	C₂₉H₃₀N₄O₈
Molecular Weight	562.57000
Exact Mass	562.20600
PSA	163.18000
LogP	0.11728
Index of Refraction	1.632

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VN2265000

CHEMICAL NAME :: Saframycin A

CAS REGISTRY NUMBER :: 66082-27-7

LAST UPDATED :: 199403

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C29-H30-N4-O8

MOLECULAR WEIGHT :: 562.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4900 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3300 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 160 ug/L

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981