2730-82-7
2730-82-7 structure
- Name: Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
- Chemical Name: N-(4-formyl-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
- CAS Number: 2730-82-7
- Molecular Formula: C23H25NO7
- Molecular Weight: 427.44700
- Catalog: Research Areas Cancer
- Create Date: 2016-04-21 07:04:42
- Modify Date: 2024-04-02 18:15:45
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4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC50 values of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1].
| Name | N-(4-formyl-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide |
|---|---|
| Synonyms |
1-Formylcolchicin
4-Formylcolchicine |
| Description | 4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC50 values of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 4-Formylcolchicine (compound 7) (0-5 µM; 24 h) shows antiproliferative activity with IC50s of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1]. Cell Viability Assay[1] Cell Line: A549, HT-29, HCT116 cells Concentration: 0-5 µM Incubation Time: 24 h Result: Inhibited cell growth with IC50s of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively. |
| References |
| Density | 1.29g/cm3 |
|---|---|
| Boiling Point | 786.9ºC at 760mmHg |
| Molecular Formula | C23H25NO7 |
| Molecular Weight | 427.44700 |
| Flash Point | 429.7ºC |
| Exact Mass | 427.16300 |
| PSA | 100.16000 |
| LogP | 3.07500 |
| Vapour Pressure | 9.93E-25mmHg at 25°C |
| Index of Refraction | 1.589 |
|
~99%
2730-82-7 |
| Literature: Yasobu, Naoko; Kitajima, Mariko; Kogure, Noriyuki; Shishido, Yoshiyuki; Matsuzaki, Takeshi; Nagaoka, Masato; Takayama, Hiromitsu ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 5 p. 348 - 352 |
![Acetamide,N-[5,6,7,9-tetrahydro-4-(hydroxymethyl)-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-,(S)- (9CI) structure](https://image.chemsrc.com/caspic/001/3986-03-6.png)