CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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DH8511000
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CHEMICAL NAME :
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Benzoic acid, 2-((3-(trifluoromethyl)phenyl)amino)-, butyl ester
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CAS REGISTRY NUMBER :
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67330-25-0
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LAST UPDATED :
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199806
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DATA ITEMS CITED :
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24
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MOLECULAR FORMULA :
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C18-H18-F3-N-O2
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MOLECULAR WEIGHT :
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337.37
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WISWESSER LINE NOTATION :
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FXFFR CMR BVO4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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510 mg/kg
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TOXIC EFFECTS :
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Behavioral - antipsychotic Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>5 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,160,1990
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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4550 mg/kg
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TOXIC EFFECTS :
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Behavioral - antipsychotic Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair
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REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>5 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,197,1995
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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650 mg/kg
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TOXIC EFFECTS :
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Behavioral - antipsychotic Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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3100 mg/kg
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TOXIC EFFECTS :
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Behavioral - antipsychotic Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair
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REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>3 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,160,1990
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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4100 mg/kg
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TOXIC EFFECTS :
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Behavioral - antipsychotic Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair
-
REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>10 gm/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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REFERENCE :
-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,160,1990
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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610 mg/kg
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TOXIC EFFECTS :
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Behavioral - antipsychotic Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
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REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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>16 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Mammal - dog
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DOSE/DURATION :
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>1 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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1500 mg/kg
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TOXIC EFFECTS :
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Behavioral - food intake (animal) Behavioral - muscle weakness Gastrointestinal - nausea or vomiting
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REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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9300 mg/kg
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TOXIC EFFECTS :
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Behavioral - food intake (animal) Behavioral - muscle weakness Gastrointestinal - nausea or vomiting
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REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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4800 mg/kg
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TOXIC EFFECTS :
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Behavioral - antipsychotic Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair
-
REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - rabbit
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DOSE/DURATION :
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>4 gm/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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11500 mg/kg
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TOXIC EFFECTS :
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Behavioral - antipsychotic Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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>10 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,845,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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3720 mg/kg/31D-I
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - other changes in urine composition Endocrine - changes in spleen weight Blood - changes in leukocyte (WBC) count
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,597,1979
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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18 gm/kg/90D-C
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TOXIC EFFECTS :
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Cardiac - changes in heart weight Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in thymus weight
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,943,1979 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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660 mg/kg
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SEX/DURATION :
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female 7-17 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - musculoskeletal system
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REFERENCE :
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KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,3288,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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990 mg/kg
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SEX/DURATION :
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female 7-17 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
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REFERENCE :
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KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,3288,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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150 mg/kg
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SEX/DURATION :
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female 17-21 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - stillbirth
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REFERENCE :
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KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,3302,1979
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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1560 mg/kg
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SEX/DURATION :
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female 6-18 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
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REFERENCE :
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AMBNAS Acta Medica et Biologica (Niigata). (Niigata Univ. School of Medicine, 1 Asahi-machi-dori, Niigata 951, Japan) V.1- 1953- Volume(issue)/page/year: 27,33,1979
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