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6024-85-7

6024-85-7 structure
6024-85-7 structure
  • Name: TETRAHYDROPALMATINE HYDROCHLORIDE
  • Chemical Name: tetrahydropalmatine hydrochloride
  • CAS Number: 6024-85-7
  • Molecular Formula: C21H26ClNO4
  • Molecular Weight: 391.888
  • Catalog: API Antipyretic analgesics Analgesic
  • Create Date: 2018-07-16 15:16:10
  • Modify Date: 2024-01-02 12:33:12
  • Tetrahydropalmatine hydrochloride (DL-Tetrahydropalmatine hydrochloride), an active component isolated from corydalis, possesses analgesic effects. Tetrahydropalmatine hydrochloride acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats[1].
Name tetrahydropalmatine hydrochloride
Synonyms Tetrahydropalmatine,HCl
corydalis B
rac-2,3,9,10-tetramethoxy-berbine,hydrochloride
2,3,9,10-Tetramethoxyberbine hydrochloride
Tetrahydropalmatini,Sulfas
rac-2,3,9,10-Tetramethoxy-berbin,Hydrochlorid
MFCD00156231
DI-TETRAHYDROPALMATINE
tetrahydro-,hydrochloride,(+-)-palmatin
Description Tetrahydropalmatine hydrochloride (DL-Tetrahydropalmatine hydrochloride), an active component isolated from corydalis, possesses analgesic effects. Tetrahydropalmatine hydrochloride acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats[1].
Target

Dopamine[1]

In Vivo Tetrahydropalmatine (THP), an active component isolated from corydalis (a Chinese herbal medicine), possesses analgesic effects. Picrotoxin treatment alone has a significant effect on the following activity measure: there is an increase in horizontal motion time (HMT), vertical motion time (VMT), clockwise turnings (CT), anticlockwise turning (ACT) and a decrease in freezing time (FT). Tetrahydropalmatine treatment alone causes a decrease in HMT, VMT and total distance traveled (TDT), but an increase in FT. Pretreatment of rats with an i.p. dose of 10 mg/kg or 15 mg/kg of Tetrahydropalmatine significantly attenuates the Picrotoxin-induced enhancement in HMT, VMT, CT, ACT and TDT, as well as reduction in FT. Another 48 rats under urethane anesthesia are randomly divided into six groups, each of eight rats. The s.c. injection of Picrotoxin causes an increase in amygdaloid release of dopamine (DA), while i.p. injection of Tetrahydropalmatine at 10 mg/kg has an insignificant effect on amygdaloid release of DA. Again, the Picrotoxin-induced increase in amygdaloid release of DA is significantly attenuated by pretreatment with Tetrahydropalmatine. The Picrotoxin-induced augmented amygdaloid release of DA is almost completely abolished by pretreatment with Tetrahydropalmatine 30 min before s.c. injection of Picrotoxin[1].
Animal Admin Rats[1] Male Sprague-Dawley rats, weighing 250-320 g, are used in the present study. The animals are housed in a temperature-regulated (22±1°C) room on 12:12 h light/dark cycles with food and water available ad libitum. The light is turned on at 06:00 h and turned off at 18:00 h. At least two major groups of animals are studied. (1) Vehicle-treated rats: received an i.p. injection of 0.9% saline plus Picrotoxin (3-4 mg/kg, s.c.). (2) Tetrahydropalmatine-treated rats: receive an injection of Tetrahydropalmatine (10 mg/kg, i.p.) plus Picrotoxin (3-4 mg/kg, s.c.). The effects of s.c. administration of Picrotoxin or Tetrahydropalmatine on locomotor activity are assessed in unanesthetized rats. On the other hand, the effects of Picrotoxin or Tetrahydropalmatine on amygdaloid DA release are assessed in rats under urethane (1.4 g/kg, i.p.) anesthesia[1]. Seventy-two unanesthetized rats are randomly divided into nine groups, each of eight rats. The animals are adapted to the behavior apparatus for 30 min before an injection of Picrotoxin (3 or 4 mg/kg, s.c.), Tetrahydropalmatine (10 or 15 mg/kg, i.p.) or saline. Then, the locomotor activities of these rats are recorded during the 30-min period following the injections[1].
References

[1]. Chang CK, et al. DL-Tetrahydropalmatine may act through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats. Neurosci Lett. 2001 Jul 20;307(3):163-6.
Boiling Point 482.9ºC at 760 mmHg
Melting Point 250-252ºC
Molecular Formula C21H26ClNO4
Molecular Weight 391.888
Flash Point 138.7ºC
Exact Mass 391.155029
PSA 40.16000
LogP 4.11640
Storage condition 2-8C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DR9840000
CHEMICAL NAME :
Berbine, 2,3,9,10-tetramethoxy-, hydrochloride, (+-)-
CAS REGISTRY NUMBER :
6024-85-7
LAST UPDATED :
199012
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H25-N-O4.Cl-H
MOLECULAR WEIGHT :
391.93
WISWESSER LINE NOTATION :
T D6 B666 KN&TT&J GO1 HO1 PO1 QO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 17,30,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
121500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 5,163,1946

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