937039-45-7

937039-45-7 structure

Name: TC-H 106
Chemical Name: N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide
CAS Number: 937039-45-7
Molecular Formula: C₂₀H₂₅N₃O₂
Molecular Weight: 339.431
Catalog: Research Areas Cancer
Create Date: 2017-08-24 22:06:15
Modify Date: 2024-01-02 21:15:07
Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs.IC50 value: 150 nM (HDAC1), 370 nM (HDAC3), 760nM(HDAC2)Target: HDAC in vitro: Pimelic diphenylamide 106 has preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1.Pimelic diphenylamide 106 exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM after a 3-h preincubation with HDAC8.

Name	N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide
Synonyms	N-(2-Aminophenyl)-N'-(4-methylphenyl)heptanediamide Pimelic Diphenylamide Heptanediamide, N-(2-aminophenyl)-N-(4-methylphenyl)- Pimelic Diphenylamide 106 TC-H 106

Description	Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs.IC50 value: 150 nM (HDAC1), 370 nM (HDAC3), 760nM(HDAC2)Target: HDAC in vitro: Pimelic diphenylamide 106 has preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1.Pimelic diphenylamide 106 exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM after a 3-h preincubation with HDAC8.
Related Catalog	Research Areas >> Cancer
Target	HDAC1:150 nM (IC50) HDAC3:370 nM (IC50) HDAC2:760 nM (IC50) HDAC8:5000 nM (IC50)
References	[1]. Chou CJ, et al. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem. 2008 Dec 19;283(51):35402-35409. [2]. Xu C, et al. Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing. Chem Biol. 2009 Sep 25;16(9):980-989.

RIDADR	NONH for all modes of transport