28874-58-0

28874-58-0 structure

Name	all-cis-docosa-7,10,13,16-tetraenoic acid
Synonyms	adrenic acid all-cis-7,10,13,16-Docosatetraenoic acid 7Z,10Z,13Z,16Z-docosatetraenoic acid Docosatetraenoic acid CIS-7,10,13,16,19-DOCOSA-TETRAENOIC ACID all-cis-docosa-7,10,13,16-tetraenoic acid (7Z,10Z,13Z,16Z)-7,10,13,16-Docosatetraenoic acid cis-7,10,13,16-DocosatetraenoicAcid DOCOSA-7Z,10Z,13Z,16Z-PENTAENOIC ACID 7,10,13,16-Docosatetraenoic acid, (7Z,10Z,13Z,16Z)- (All-Z)-7,10,13,16-docosatetraenoic acid CIS-7,10,13,16-DOCOSA-TETRAENOIC ACID DOCOSA-7Z,10Z,13Z,16Z-TETRAENOIC ACID

Description	Adrenic Acid is an inflammation enhancer in non-alcoholic fatty liver disease.
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Natural Products >> Others
Target	Human Endogenous Metabolite
In Vitro	Adrenic acid is produced via the elongation of arachidonic acid by ELOVL2 and 5. Interestingly, the hepatic level of free Adrenic Acid (22:4n6) is markedly higher in the CDAHFD-fed db/db mice than in the SD-fed db/db mice. In plasma, the difference in the adrenic acid level reaches statistical significance (p<0.001). It is also found that the concentrations of phospholipid species containing Adrenic Acid, such as PC or PE (40:4) (containing side chain 18:0/22:4), and LPC 22:4 (sn-1/sn-2), are also significantly increased. (sn-1/sn-2). The hepatic and plasma levels of Adrenic Acid, which is an omega 6 polyunsaturated fatty acid (PUFA), exhibit greater differences between the CDAHFD-fed db/db mice and the SD-fed db/db mice (8.6-fold higher vs. 1.6-fold higher in liver tissue, 5.3-fold higher vs. 2.2-fold higher in plasma) than those of well-known proinflammatory PUFA, such as Arachidonic Acid[1].
References	[1]. SautHoras H Nababan, et al. Adrenic acid as an inflammation enhancer in non-alcoholic fatty liver disease. Arch Biochem Biophys. 2017 Jun 1;623-624:64-75.

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