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109683-61-6

109683-61-6 structure
109683-61-6 structure
  • Name: Utibapril
  • Chemical Name: 5-tert-butyl-3-[2-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]propanoyl]-2H-1,3,4-thiadiazole-2-carboxylic acid
  • CAS Number: 109683-61-6
  • Molecular Formula: C22H31N3O5S
  • Molecular Weight: 449.56400
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
  • Create Date: 2018-05-12 08:00:00
  • Modify Date: 2024-01-08 17:41:59
  • Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities.

Name 5-tert-butyl-3-[2-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]propanoyl]-2H-1,3,4-thiadiazole-2-carboxylic acid
Synonyms Utibaprilo
Utibaprilo [INN-Spanish]
5-tert-butyl-3-[n-(1-ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl]-2,3-dihydro-1,3,4-thiadiazole-2-carboxylic acid
Utibapril
Utibaprilum [INN-Latin]
Utibaprilum
5-tert-butyl-3-{N-[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl}-2,3-dihydro-1,3,4-thiadiazole-2(S)-carboxylic acid
Description Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities.
Related Catalog
In Vivo Utibapril significantly inhibits plasma, renal, and vascular ACE but not ventricular ACE activity. Utibapril (2 μg/kg/day) significantly inhibits vascular ACE activity, and Utibapril (250 μg/kg/day) results in a significant inhibition of plasma ACE. Furthermore, angiotensin I-induced decreases in coronary flow in the isolated heart are significantly inhibited after treatment with the higher doses of utibapril[1]. FPL 63547 is rapidly and extensively excreted as the diacid in the bile but appeared in the urine in negligible amounts[2].
References

[1]. Buikema H, et al. Differential inhibition of plasma versus tissue ACE by utibapril: biochemical and functional evidence for inhibition of vascular ACE activity. J Cardiovasc Pharmacol. 1997 May;29(5):684-91.

[2]. Carr RD, et al. Preferential biliary elimination of FPL 63547, a novel inhibitor of angiotensin-converting enzyme, in the rat. Br J Pharmacol. 1990 May;100(1):90-4.

Density 1.24g/cm3
Boiling Point 597.5ºC at 760 mmHg
Molecular Formula C22H31N3O5S
Molecular Weight 449.56400
Flash Point 315.2ºC
Exact Mass 449.19800
PSA 133.60000
LogP 2.63910
Vapour Pressure 3.98E-15mmHg at 25°C
Index of Refraction 1.586
Storage condition 2-8℃