Name | 5-tert-butyl-3-[2-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]propanoyl]-2H-1,3,4-thiadiazole-2-carboxylic acid |
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Synonyms |
Utibaprilo
Utibaprilo [INN-Spanish] 5-tert-butyl-3-[n-(1-ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl]-2,3-dihydro-1,3,4-thiadiazole-2-carboxylic acid Utibapril Utibaprilum [INN-Latin] Utibaprilum 5-tert-butyl-3-{N-[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl}-2,3-dihydro-1,3,4-thiadiazole-2(S)-carboxylic acid |
Description | Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities. |
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Related Catalog | |
In Vivo | Utibapril significantly inhibits plasma, renal, and vascular ACE but not ventricular ACE activity. Utibapril (2 μg/kg/day) significantly inhibits vascular ACE activity, and Utibapril (250 μg/kg/day) results in a significant inhibition of plasma ACE. Furthermore, angiotensin I-induced decreases in coronary flow in the isolated heart are significantly inhibited after treatment with the higher doses of utibapril[1]. FPL 63547 is rapidly and extensively excreted as the diacid in the bile but appeared in the urine in negligible amounts[2]. |
References |
Density | 1.24g/cm3 |
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Boiling Point | 597.5ºC at 760 mmHg |
Molecular Formula | C22H31N3O5S |
Molecular Weight | 449.56400 |
Flash Point | 315.2ºC |
Exact Mass | 449.19800 |
PSA | 133.60000 |
LogP | 2.63910 |
Vapour Pressure | 3.98E-15mmHg at 25°C |
Index of Refraction | 1.586 |
Storage condition | 2-8℃ |