CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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SS9625000
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CAS REGISTRY NUMBER :
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6283-63-2
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LAST UPDATED :
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199410
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DATA ITEMS CITED :
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14
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MOLECULAR FORMULA :
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C10-H16-N2.H2-O4-S
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MOLECULAR WEIGHT :
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262.36
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WISWESSER LINE NOTATION :
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ZR DN2&2 &S-O4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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100 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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100 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intratracheal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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50 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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450 mg/kg
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TOXIC EFFECTS :
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Behavioral - excitement Behavioral - ataxia Behavioral - muscle contraction or spasticity
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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300 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - rigidity (including catalepsy) Blood - methemoglobinemia-carboxyhemoglobin
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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80 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - rigidity (including catalepsy) Blood - methemoglobinemia-carboxyhemoglobin
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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318 mg/kg
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TOXIC EFFECTS :
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Behavioral - excitement Behavioral - ataxia Behavioral - muscle contraction or spasticity
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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560 mg/kg
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TOXIC EFFECTS :
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Behavioral - excitement Behavioral - ataxia Behavioral - muscle contraction or spasticity
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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10920 ug/kg/26W-I
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TOXIC EFFECTS :
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Liver - other changes Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2745 mg/kg/61D-I
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TOXIC EFFECTS :
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Blood - pigmented or nucleated red blood cells Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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244 mg/kg/61D-I
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TOXIC EFFECTS :
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Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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36 mg/kg
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SEX/DURATION :
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male 60 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
MUTATION DATA
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TYPE OF TEST :
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Mutation in microorganisms
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TEST SYSTEM :
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Bacteria - Salmonella typhimurium
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DOSE/DURATION :
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8 mg/plate
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REFERENCE :
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MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 238,1,1990
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