110374-16-8

110374-16-8 structure

Name: 4-Desmethoxy Omeprazole
Chemical Name: 2-[(3,5-dimethylpyridin-2-yl)methylsulfinyl]-6-methoxy-1H-benzimidazole
CAS Number: 110374-16-8
Molecular Formula: C₁₆H₁₇N₃O₂S
Molecular Weight: 315.390
Catalog: Research Areas Cancer
Create Date: 2018-10-04 01:11:25
Modify Date: 2024-01-21 12:48:27
4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].

Name	2-[(3,5-dimethylpyridin-2-yl)methylsulfinyl]-6-methoxy-1H-benzimidazole
Synonyms	2-[[(3,5-Dimethyl-2-pyridinyl)methyl]sulfinyl]-6-methoxy-1H-benzimidazole 2-(((3,5-Dimethylpyridin-2-yl)methyl)sulfinyl)-5-methoxy-1H-benzo[d]imidazole Omeprazole impurity B [EP] 4-Desmethoxy Omeprazole UNII:0S4HQG5KFN UNII-0S4HQG5KFN 1H-Benzimidazole, 2-[[(3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-5-methoxy- 2-{[(3,5-Dimethyl-2-pyridinyl)methyl]sulfinyl}-5-methoxy-1H-benzimidazole Omeprazole magnesium impurity B [EP] Esomeprazole Impurity 2

Description	4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Research Areas >> Metabolic Disease
References	[1]. Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7. [2]. Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37(1):145-50.

Hazard Codes	Xi
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%