Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, monohydrochloride
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65896-14-2

65896-14-2 structure

Name: 1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, monohydrochloride
Chemical Name: Romifidine Hydrochloride
CAS Number: 65896-14-2
Molecular Formula: C₉H₁₀BrClFN₃
Molecular Weight: 294.55100
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2016-09-19 01:15:30
Modify Date: 2024-01-08 18:34:26
Romifidine hydrochloride is an α2 adrenergic receptor agonist. Romifidine hydrochloride shows sedation effects in vivo[1][2].

Name	Romifidine Hydrochloride
Synonyms	N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine,hydrochloride

Description	Romifidine hydrochloride is an α2 adrenergic receptor agonist. Romifidine hydrochloride shows sedation effects in vivo[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
In Vivo	Romifidine hydrochloride (80 μg/kg; i.v. once) produces sedative effects with significantly greater drooping during the 45-90 min time period in welsh mountain ponies[1]. Romifidine hydrochloride (40, 80 and 120 mg/kg; i.v. at seven-day intervals) shows a shallower and shorter-lived sedation than with detomidine in horses[2].
References	[1]. England GC, et al. A comparison of the sedative effects of three alpha 2-adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse. J Vet Pharmacol Ther. 1992 Jun;15(2):194-201. [2]. Hamm D, et al. Sedative and analgesic effects of detomidine and romifidine in horses. Vet Rec. 1995 Apr 1;136(13):324-7.