Name | Isoprenaline sulphate |
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Synonyms |
4-{1-Hydroxy-2-[(1-methylethyl)amino]ethyl}benzol-1,2-diolsulfat(2:1)(salt)
aleudrin Novodrine 4-[1-Hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol sulfate (2:1) 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, sulfate (2:1) (salt) UNII:052RYF6JDD 4-{1-hydroxy-2-[(1-méthyléthyl)amino]éthyl}benzène-1,2-diol sulfate (2:1) (salt) 4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}benzene-1,2-diol sulfate (2:1) (salt) 4-[1-Hydroxy-2-(isopropylamino)ethyl]-1,2-benzenediol sulfate (2:1) Isoprenaline Sulfate Dihydrate EINECS 206-085-2 dl-Isoprenaline sulfate medihaler-iso ISO PROTERENOL SULPHATE Isoproterenol Sulfate Dihydrate Isoprenaline sulfate Novodrin isoprenalinesulfate(2:1) isoprenalinesulphate |
Description | Isoprenaline hemisulfate is a non-selective β-adrenergic receptor agonist with potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities[1][2][3][4][5]. |
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Related Catalog | |
Target |
Beta-adrenergic receptor Human Endogenous Metabolite |
In Vitro | Isoprenaline (300 nM, 3 min) increases particulate cGMP- and cilostamide-inhibited, low-Km cAMP phosphodiesterase (cAMP-PDE) activity by about 100% in intact rat fat cells[1]. Isoprenaline inhibits insulin-stimulated glucose transport activity in rat adipocytes. Isoprenaline, in the absence of adenosine, promotes a time-dependent (t1/2 approximately 2 min) decrease in the accessibility of insulin-stimulated cell surface GLUT4 of > 50%, which directly correlated with the observed inhibition of transport activity[2]. Isoprenaline (5 nM and 10 μM) increases cyclic AMP levels and this effect is potentiated by cilostamide (10 mM), by rolipram, a cyclic AMP-specific PDE (PDE 4) inhibitor (10 mM) and by cyclic GMP-elevating agents (50 nM ANF or 30 nM SNP plus 100 nM DMPPO)[3]. Isoprenaline increases the transcriptional activity of Gi alpha-2 gene to 140% of the control value, whereas gene specific hybridization for Gs alpha remains unchanged[4]. Isoprenaline (20 nM) increases the amplitude of total iK and causes a negative shift of approximately 10 mV in the activation curve for iK, both in the absence and in the presence of 300 nM nisoldipine to block the L-type Ca2+ current. Isoprenaline (20 nM) increases the spontaneous pacemaker rate of sino-atrial node pacemaker cells by 16% in rabbit isolated pacemaker cells[5]. |
References |
Boiling Point | 417.5ºC at 760 mmHg |
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Molecular Formula | C22H36N2O10S |
Molecular Weight | 520.594 |
Flash Point | 179.7ºC |
Exact Mass | 520.209045 |
PSA | 228.42000 |
LogP | 3.46820 |
Vapour Pressure | 1.02E-07mmHg at 25°C |
Water Solubility | almost transparency |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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HS Code | 2922509090 |
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Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |