141750-63-2

141750-63-2 structure

Name: Pitavastatin lactone
Chemical Name: Pitavastatin lactone
CAS Number: 141750-63-2
Molecular Formula: C₂₅H₂₂FNO₃
Molecular Weight: 403.445
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-06-27 19:37:45
Modify Date: 2024-01-10 18:53:14
Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes[1].

Name	Pitavastatin lactone
Synonyms	2H-Pyran-2-one, 6-[(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-, (4R,6S)- (4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one Pitavastatinlactone Pitavastatin Impurity 4

Description	Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes[1].
Related Catalog	Research Areas >> Cardiovascular Disease
References	[1]. Fujino H, et al. Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. Xenobiotica. 2003 Jan;33(1):27-41.