268214-52-4
268214-52-4 structure
- Name: Coronalolic acid
- Chemical Name: 3-[(1R,3aS,3bS,6R,6aR,7aS,9aR)-6-(3-Hydroxy-1-propen-2-yl)-3a,9a- dimethyl-1-[(2R,5E)-6-methyl-7-oxo-5-hepten-2-yl]decahydro-1H-cyc lopenta[a]cyclopropa[e]naphthalen-6a(7H)-yl]propanoic acid
- CAS Number: 268214-52-4
- Molecular Formula: C30H46O4
- Molecular Weight: 470.684
- Catalog: Natural product Moss
- Create Date: 2016-08-20 01:33:54
- Modify Date: 2024-01-08 17:41:05
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Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced NF-κB activity and NO production[1].
| Name | 3-[(1R,3aS,3bS,6R,6aR,7aS,9aR)-6-(3-Hydroxy-1-propen-2-yl)-3a,9a- dimethyl-1-[(2R,5E)-6-methyl-7-oxo-5-hepten-2-yl]decahydro-1H-cyc lopenta[a]cyclopropa[e]naphthalen-6a(7H)-yl]propanoic acid |
|---|---|
| Synonyms |
Coronalolic acid
1H-Cyclopenta[a]cyclopropa[e]naphthalene-6a(7H)-propanoic acid, 1-[(1R,4E)-1,5-dimethyl-6-oxo-4-hexen-1-yl]decahydro-6-[1-(hydroxymethyl)ethenyl]-3a,9a-dimethyl-, (1R,3aS,3bS,6R,6aR,7aS,9aR)- 3-[(1R,3aS,3bS,6R,6aR,7aS,9aR)-6-(3-Hydroxy-1-propen-2-yl)-3a,9a-dimethyl-1-[(2R,5E)-6-methyl-7-oxo-5-hepten-2-yl]decahydro-1H-cyclopenta[a]cyclopropa[e]naphthalen-6a(7H)-yl]propanoic acid |
| Description | Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced NF-κB activity and NO production[1]. |
|---|---|
| Related Catalog | |
| Target |
NF-κB |
| In Vitro | Coronalolic acid has an inhibition effect against the TNF-α-induced NF-κB activity and NO production with IC50s of 15.4 μM and 15.0 μM in LPS-stimulated RAW 264.7 cells, respectively[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 608.7±25.0 °C at 760 mmHg |
| Molecular Formula | C30H46O4 |
| Molecular Weight | 470.684 |
| Flash Point | 335.9±19.7 °C |
| Exact Mass | 470.339600 |
| PSA | 74.60000 |
| LogP | 7.24 |
| Vapour Pressure | 0.0±4.0 mmHg at 25°C |
| Index of Refraction | 1.551 |
| Hazard Codes | Xi |
|---|