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851636-83-4

851636-83-4 structure
851636-83-4 structure
  • Name: Cysmethynil
  • Chemical Name: 2-[5-(3-methylphenyl)-1-octylindol-3-yl]acetamide
  • CAS Number: 851636-83-4
  • Molecular Formula: C25H32N2O
  • Molecular Weight: 376.53400
  • Catalog: Signaling Pathways Autophagy Autophagy
  • Create Date: 2017-05-05 14:04:40
  • Modify Date: 2024-01-03 12:48:07
  • Cysmethynil is an Icmt inhibitor(IC50 = 2.4 μM). Cysmethynil inhibites RAS membrane binding and EGF signal transduction. Cysmethynil prevents the cells in the G1 phase and induces autophagy. Cysmethynil inhibits PC3 cells proliferation, has synergistic effect with Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A). Cysmethynil has anti-tumor effects and can be used for solid tumor (such as prostate cancer et al.) research[1][2][3].

Name 2-[5-(3-methylphenyl)-1-octylindol-3-yl]acetamide
Synonyms 9J20
1H-Indole-3-acetamide, 5-(3-methylphenyl)-1-octyl-
2-[5-(3-Methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
Cysmethynil
1H-Indole-3-acetamide,5-(3-methylphenyl)-1-octyl
Description Cysmethynil is an Icmt inhibitor(IC50 = 2.4 μM). Cysmethynil inhibites RAS membrane binding and EGF signal transduction. Cysmethynil prevents the cells in the G1 phase and induces autophagy. Cysmethynil inhibits PC3 cells proliferation, has synergistic effect with Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A). Cysmethynil has anti-tumor effects and can be used for solid tumor (such as prostate cancer et al.) research[1][2][3].
Related Catalog
Target

IC50 = 2.4 μM for Icmt

References

[1]. Winter-Vann AM, et al. A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4336-41.  

[2]. Wang M, et al. A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. J Biol Chem. 2008 Jul 4;283(27):18678-84.  

[3]. Pan Q, et al. Inhibition of isoprenylcysteine carboxylmethyltransferase sensitizes common chemotherapies in cervical cancer via Ras-dependent pathway. Biomed Pharmacother. 2018 Mar;99:169-175.  

[4]. Zhu C, et al. Targeting KRAS mutant cancers: from druggable therapy to drug resistance. Mol Cancer. 2022 Aug 4;21(1):159.  

Molecular Formula C25H32N2O
Molecular Weight 376.53400
Exact Mass 376.25100
PSA 49.01000
LogP 7.15470