114776-28-2
114776-28-2 structure
- Name: Bepafant
- Chemical Name: Bepafant
- CAS Number: 114776-28-2
- Molecular Formula: C23H22ClN5O2S
- Molecular Weight: 467.97100
- Create Date: 2018-06-26 18:08:05
- Modify Date: 2024-04-06 10:13:45
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Bepafant, also known as WEB-2170 and STY-2108, is a platelet activating factor (PAF) antagonist potentially for the treatment of asthma. Bepafant triggered apoptosis in NB4, KG1, and NB4-MR4 cells where PTEN was expressed, but not in THP1 and U937 cells where PTEN was absent. Bepafant may produce significant anti-inflammatory effects.
| Name | Bepafant |
|---|---|
| Synonyms |
6-(2-chlorophenyl)-8,9-dihydro-1-methyl-8-[(4-morpholinyl)carbonyl]-4H,7H-cyclopenta-[4,5]thieno-[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
Web 2170 4-((6-(o-chlorophenyl)-8,9-dihydro-1-methyl-4h,7h-cyclopenta[4,5]thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepin-8-yl)carbonyl)morpholine Bepafanto [INN-Spanish] |
| Density | 1.59g/cm3 |
|---|---|
| Boiling Point | 744.5ºC at 760mmHg |
| Molecular Formula | C23H22ClN5O2S |
| Molecular Weight | 467.97100 |
| Flash Point | 404.1ºC |
| Exact Mass | 467.11800 |
| PSA | 100.85000 |
| LogP | 2.58870 |
| Vapour Pressure | 4.86E-22mmHg at 25°C |
| Index of Refraction | 1.792 |