Name | [d-pro2, d-trp7,9]-substance p |
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Synonyms |
2-Pro-7,9-Trp-substance p
2-Pro-7,9-Trp-sp Pttsp Pt-sp <D-Pro2,D-Trp7,9>-SP dt79 [DPro2,DTrp7,9] Substance P |
Description | [D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist[1][2]. |
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Related Catalog | |
In Vitro | [D-Pro2,D-Trp7,9] Substance P decreases proliferation only in a few cell lines, and only in the highest concentration (100 µM). [D-Pro2,D-Trp7,9] Substance P displays a significantly weaker antiproliferative action than Aprepitant (HY-10052) on cancer or normal cell lines[3]. |
In Vivo | [D-Pro2,D-Trp7,9] Substance P (0-30 nmol, Intravitreal injection) greatly reduces not only the effects of exogenous Substance P (HY-P0201) but also the inflammatory response to trauma to the eye[1]. [D-Pro2,D-Trp7,9] Substance P specifically antagonizes the contractile effects of Substance P on the guinea-pig isolated taenia coli[2]. Animal Model: Adult pigmented rabbits (1.5-3 kg)[1] Dosage: 0.03, 0.3, 3, and 30 nmol Administration: Intravitreal injection or topical application onto the eye, 60 μL Result: Reduced the inflammatory response to Substance P. Dependently reduced the inflammatory response to infrared irradiation. In itself, intravitreal injection of low doses of [D-Pro2, D-Trp7'9]SP had no effects on the eye. |
References |
Molecular Formula | C74H106N20O13S |
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Molecular Weight | 1515.82000 |
Exact Mass | 1514.80000 |
PSA | 573.51000 |
LogP | 6.76800 |