60563-36-2

60563-36-2 structure

Name: DCEBIO
Chemical Name: 5,6-dichloro-3-ethyl-1H-benzimidazol-2-one
CAS Number: 60563-36-2
Molecular Formula: C₉H₈Cl₂N₂O
Molecular Weight: 231.08
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2018-12-21 16:12:42
Modify Date: 2024-01-30 20:42:30
DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl－ secretion in T84 colonic cells[1]. DCEBIO stimulates Cl－ secretion via the activation of hIK1 K＋ channels and the activation of an apical membrane Cl－ conductance[2].

Name	5,6-dichloro-3-ethyl-1H-benzimidazol-2-one
Synonyms	5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazole-2-one 5,6-dichloro-1-ethyl-1,3-dihydro-benzoimidazol-2-one DC-EBIO 5,6-dichloro-3-ethyl benzimidazolone 5,6-Dichlor-1-ethyl-benzimidazolon 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one 5,6-dichloro-1-ethyl-benzimidazolinone Tocris-1422 5,6-Dichlor-2-oxo-1-ethyl-benzimidazolin dichloro-EBIO

Description	DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl－ secretion in T84 colonic cells[1]. DCEBIO stimulates Cl－ secretion via the activation of hIK1 K＋ channels and the activation of an apical membrane Cl－ conductance[2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	Cl－ secretion[1]
References	[1]. Hamilton KL,et al. DCEBIO stimulates Cl- secretion in the mouse jejunum. Am J Physiol Cell Physiol. 2006 Jan;290(1):C152-64. [2]. Singh S, et al. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%