82801-73-8

82801-73-8 structure

Name: RKRARKE
Chemical Name: cGMP Dependent Kinase Inhibitor Peptide
CAS Number: 82801-73-8
Molecular Formula: C₃₈H₇₄N₁₈O₁₀
Molecular Weight: 943.11
Catalog: Research Areas Cancer
Create Date: 2018-12-31 17:37:55
Modify Date: 2024-01-02 09:36:44
PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM[1].

Name	cGMP Dependent Kinase Inhibitor Peptide
Synonyms	L-Glutamic acid, N-(diaminomethylene)-L-ornithyl-L-lysyl-N-(diaminomethylene)-L-ornithyl-L-alanyl-N-(diaminomethylene)-L-ornithyl-L-lysyl- Alg-Lys-Arg-Ala-Arg-Lys-Glu cGMP-Dependent Protein Kinase Inhibitor Peptide ARG-LYS-ARG-ALA-ARG-LYS-GLU arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid RKRARKE PKG INHIBITOR PROTEIN KINASE G INHIBITOR N-(Diaminomethylene)-L-ornithyl-L-lysyl-N-(diaminomethylene)-L-ornithyl-L-alanyl-N-(diaminomethylene)-L-ornithyl-L-lysyl-L-glutamic acid H-ARG-LYS-ARG-ALA-ARG-LYS-GLU-OH

Description	PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	Ki: 86 μM (PKG)[1]
In Vitro	Summary of experiments showing that intracellular dialysis of postsynaptic cells with PKG inhibitor PKG inhibitor peptide (1 mM) failed to alter the induction of long-term depression (CCh-LTD)[2].
References	[1]. Bhatnagar D, et al. Synthetic peptide analogues differentially alter the binding affinities of cyclic nucleotide dependent protein kinases for nucleotide substrates. Biochemistry. 1988 Mar 22;27(6):1988-94. [2]. Chiung-Chun Huang, et al. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex. 2010 Apr;20(4):982-96.