Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TyrphostinAG835
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Purity: 98.0%
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133550-37-5

133550-37-5 structure

133550-37-5 structure

Name: Tyrphostin AG 835
Chemical Name: Tyrphostin B44, (+) enantiomer,(S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide
CAS Number: 133550-37-5
Molecular Formula: C₁₈H₁₆N₂O₃
Molecular Weight: 308.33100
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2017-05-19 18:22:25
Modify Date: 2024-01-09 18:29:20
(+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) is an EGRF inhibitor with antitumor activities[1].

Name	Tyrphostin B44, (+) enantiomer,(S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide
Synonyms	AG 835 TYRPHOSTIN AG 835 Tyrphostin AG 835 TYRPHOSTIN B50

Description	(+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) is an EGRF inhibitor with antitumor activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
In Vitro	(+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) (0-100 µM) inhibits cell survival with EC50 values of 3.12, 12.5 and 12.5 µM against CALO, INBL and HeLa cells, respectively[1].
References	[1]. Soto-Cruz I, et al. The tyrphostin B42 inhibits cell proliferation and HER-2 autophosphorylation in cervical carcinoma cell lines. Cancer Invest. 2008 Mar;26(2):136-44.

Density	1.299g/cm3
Boiling Point	603ºC at 760mmHg
Melting Point	146 °C
Molecular Formula	C₁₈H₁₆N₂O₃
Molecular Weight	308.33100
Flash Point	318.5ºC
Exact Mass	308.11600
PSA	93.35000
LogP	3.27308
Vapour Pressure	3.9E-15mmHg at 25°C
Index of Refraction	1.66

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22
RIDADR	NONH for all modes of transport