331859-86-0
331859-86-0 structure
- Name: Chromeceptin
- Chemical Name: Chromeceptin
- CAS Number: 331859-86-0
- Molecular Formula: C19H16F3N3O
- Molecular Weight: 359.34500
- Catalog: Signaling Pathways PI3K/Akt/mTOR Akt
- Create Date: 2017-08-13 08:52:47
- Modify Date: 2024-01-16 19:18:54
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Chromeceptin is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the Phosphorylation levels of AKT and mTOR[1].
| Name | Chromeceptin |
|---|---|
| Synonyms |
2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene 94G6
2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile |
| Description | Chromeceptin is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the Phosphorylation levels of AKT and mTOR[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Chromeceptin (94G6) (5 µM) inhibits IGF2 expression in Hep3B-derived TS cells in a time-dependent manner[1]. Chromeceptin decreases the Phosphorylation levels of protein kinase B (AKT, Ser463) and rapamycin (mTOR, Ser 2481 and Ser 2448) in TS cells[1]. Chromeceptin represses the phosphorylation at ser371 in mTOR effectors ribosomal protein S6 kinase (p70S6K)[1]. |
| References |
| Molecular Formula | C19H16F3N3O |
|---|---|
| Molecular Weight | 359.34500 |
| Exact Mass | 359.12500 |
| PSA | 62.28000 |
| LogP | 4.68988 |
| Storage condition | 20°C |
| RIDADR | NONH for all modes of transport |
|---|
