25459-91-0

25459-91-0 structure

Name: Demethyleneberberine
Chemical Name: 9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol
CAS Number: 25459-91-0
Molecular Formula: C₁₉H₁₈NO₄+
Molecular Weight: 323.34300
Catalog: Signaling Pathways Epigenetics AMPK
Create Date: 2018-09-23 16:56:00
Modify Date: 2024-01-03 16:22:04
Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine could serve as a AMPK activator for treating non-alcoholic fatty liver disease (NAFLD)[1][2][3].

Name	9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol
Synonyms	demethyleneberberine 2,3-Dihydroxy-9,10-dimethoxy-7,8,13,14-tetradehydro-berbinium 2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-dihydroxy-berbinium 2,3-dihydroxy-9,10-dimethoxy-5,6-dihydro-isoquino[3,2-a]isoquinolinylium Demethylen-berberin Dibenzo[a,g]quinolizinium,5,6-dihydro-2,3-dihydroxy-9,10-dimethoxy

Description	Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine could serve as a AMPK activator for treating non-alcoholic fatty liver disease (NAFLD)[1][2][3].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Inflammation/Immunology Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Research Areas >> Metabolic Disease
References	[1]. Zhang P, et al. Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model. J Pharmacol Exp Ther. 2015 Jan;352(1):139-47. [2]. Chen YY, et al. Demethyleneberberine alleviates inflammatory bowel disease in mice through regulating NF-κB signaling and T-helper cell homeostasis. Inflamm Res. 2017 Feb;66(2):187-196. [3]. Qiang X, et al. Demethyleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress. Biochem Biophys Res Commun. 2016 Apr 15;472(4):603-9.

633-65-8

~43%

25459-91-0

Literature: XINTRIA PHARMACEUTICAL CORPORATION, INC.; LIPPA, Arnold, Stan Patent: WO2010/104595 A1, 2010 ; Location in patent: Page/Page column 103 ;

51-61-6

25459-91-0

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1380 - 1383

86-51-1

25459-91-0

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1380 - 1383

Precursor 3
633-65-8 51-61-6 86-51-1
DownStream 0