3432-99-3
3432-99-3 structure
- Name: folitixorin
- Chemical Name: (6R)-5,10-methylenetetrahydrofolic acid
- CAS Number: 3432-99-3
- Molecular Formula: C20H23N7O6
- Molecular Weight: 457.440
- Catalog: Research Areas Cancer
- Create Date: 2017-06-05 00:58:43
- Modify Date: 2024-01-04 11:13:28
-
Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research[1][2].
| Name | (6R)-5,10-methylenetetrahydrofolic acid |
|---|---|
| Synonyms |
UNII:0SXY5ET48B
5,10-methylenetetrahydrofolate 5,10-Methylenetetrahydrofolic acid folitixorin Tetrahydromethylenefolate L-glutamic acid, N-[4-(3-amino-5,6,6a,7-tetrahydro-1-hydroxyimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]- N-[4-(3-amino-1-hydroxy-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-L-glutamic acid (2S)-2-[[4-(3-amino-1-oxo-4,5,6,6a,7,9-hexahydroimidazo[1,5-f]pteridin-8-yl)benzoyl]amino]pentanedioic acid L-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]- CH2H4folate N5,N10-Methyl-enetetrahydrofolic Acid N-[4-(3-Amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-L-glutamic acid |
| Description | Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate into 5-methyltetrahy-drofolate, which is the major circulating form of folate[3]. |
| In Vivo | A colon adenocarcinoma cell suspension is inoculated intrahepatically in a rodent experimental model. Intravenous 5-FU (30 mg/kg) in combination with Folitixorin (15 mg/kg or 30 mg/kg) is administered after 1, 2, 3, 4 and 7 days. 5-FU in combination with Folitixorin (regardless of folate-dose) eliminats tumor take[1]. |
| References |
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H23N7O6 |
| Molecular Weight | 457.440 |
| Exact Mass | 457.170990 |
| PSA | 194.97000 |
| LogP | -2.87 |
| Index of Refraction | 1.801 |
| Storage condition | -20°C |
