835876-32-9
835876-32-9 structure
- Name: Platensimycin
- Chemical Name: platensimycin
- CAS Number: 835876-32-9
- Molecular Formula: C24H27NO7
- Molecular Weight: 441.474
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2016-03-08 06:51:51
- Modify Date: 2024-01-02 20:53:25
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Platensimycin is an antibiotic produced by S. platensis that inhibits gram-positive bacteria by selectively inhibiting cellular lipid biosynthesis (IC50=0.1 μM). Platensimycin targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s=48 nM and 160 nM for S.aureus and E.coli enzymes, respectively). Platensimycin is a promising agent for overcoming antibiotic resistance.
| Name | platensimycin |
|---|---|
| Synonyms |
Benzoic acid, 3-[[3-[(1S,3S,4S,5aS,9S,9aR)-1,4,5,8,9,9a-hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5a-dimethano-2-benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxy-
3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxo-1,2,5,6,7,8,9,9a-octahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid Platensimycin 3-({3-[(1S,5S,6R,7S,9S,10S)-5,9-Dimethyl-4-oxo-8-oxatetracyclo[7.2.1.1.0]tridec-2-en-5-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid |
| Description | Platensimycin is an antibiotic produced by S. platensis that inhibits gram-positive bacteria by selectively inhibiting cellular lipid biosynthesis (IC50=0.1 μM). Platensimycin targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s=48 nM and 160 nM for S.aureus and E.coli enzymes, respectively). Platensimycin is a promising agent for overcoming antibiotic resistance. |
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| Related Catalog |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 683.1±55.0 °C at 760 mmHg |
| Molecular Formula | C24H27NO7 |
| Molecular Weight | 441.474 |
| Flash Point | 366.9±31.5 °C |
| Exact Mass | 441.178741 |
| PSA | 136.65000 |
| LogP | 3.00 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.670 |
| RIDADR | NONH for all modes of transport |
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