41598-07-6

41598-07-6 structure

Name: Prostaglandin D2
Chemical Name: prostaglandin D2
CAS Number: 41598-07-6
Molecular Formula: C₂₀H₃₂O₅
Molecular Weight: 352.465
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-03-02 08:00:00
Modify Date: 2024-01-01 22:31:25
Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

Name	prostaglandin D2
Synonyms	PGD2 (5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic acid Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9α,13E,15S)- Prostaglandin D2 (5Z,9α,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oic acid MFCD00077857

Description	Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	Human Endogenous Metabolite
In Vivo	Prostaglandin D2 (PGD2; infused into the lateral ventricle; 5-50 pmol/min; for 6 hours between 20:00 and 2:00) induces sleep-wake profiles in A2AR KO mice[2]. Animal Model: Male WT and A2AR KO mice of the inbred C57BL/6 strain (weighing 23-27 g, 11-13 weeks old)[1] Dosage: 5, 10, 20, or 50 pmol/min Administration: Infused into the lateral ventricle; for 6 hours between 20:00 and 2:00 Result: Induced sleep-wake profiles.
References	[1]. Suzuki F, et al. Transport of prostaglandin D2 into brain. Brain Res. 1986 Oct 22;385(2):321-8. [2]. Zhang BJ, et al. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. Acta Pharmacol Sin. 2017 Apr;38(4):469-476. [3]. Kida T, et al. Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One. 2016 Dec 19;11(12):e0167729.

CHEMICAL NAME :: Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9-alpha,13E,15S)-

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 46,1688,1986

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H360
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	60-22
Safety Phrases	S22;S26;S36;S53
RIDADR	NONH for all modes of transport
RTECS	UK7930000