51555-87-4

51555-87-4 structure

Name: Thiodigalactoside
Chemical Name: thiodigalactoside
CAS Number: 51555-87-4
Molecular Formula: C₁₂H₂₂O₁₀S
Molecular Weight: 358.36200
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-02-05 06:06:13
Modify Date: 2024-01-14 14:33:53
Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively[1]. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats[2].

Name	thiodigalactoside
Synonyms	D-Galactopyranosyl-b-D-thiogalactopyranoside

Description	Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively[1]. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	Kd: 24 μM (GAL1) and 49 μM (GAL3)[1]
In Vitro	Thiodigalactoside (TDG; 250 and 500 μM) exhibits dose-dependent reduction of fat accumulation based on triglyceride (TG) content and Oil Red O (ORO) staining[1].
In Vivo	Thiodigalactoside (TDG; 5 mg/kg; IP; once per week for 5 weeks) results in dramatic inhibition of HFD-induced body weight gain[2]. Thiodigalactoside (5 mg/kg; oral; daily or weekly for 5 weeks) gave less reduction in body weight gain compare with i.p.[2]. Animal Model: Five-week-old Sprague-Dawley (SD) male rats[2] Dosage: 5 mg/kg Administration: IP; once per week for 5 weeks Result: Resulted in dramatic inhibition of HFD-induced body weight gain by inhibiting adipogenesis and lipogensis as well as by increasing expression of the proteins associated with thermogenesis and energy expenditure.
References	[1]. Hilde van Hattum, et al. Tuning the Preference of Thiodigalactoside- And Lactosamine-Based Ligands to galectin-3 Over galectin-1. J Med Chem. 2013 Feb 14;56(3):1350-4. [2]. Varun V Prabhu, et al. Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner. Cancer Res. 2015 Apr 1;75(7):1423-32.

Molecular Formula	C₁₂H₂₂O₁₀S
Molecular Weight	358.36200
Exact Mass	358.09300
PSA	205.60000

WGK Germany	3

19879-84-6

3068-32-4

51555-87-4

Literature: Bogusiak, Jadwiga; Szeja, Wieslaw Carbohydrate Research, 1985 , vol. 141, p. 165 - 167

Precursor 2
19879-84-6 3068-32-4
DownStream 0

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