CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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WE6660000
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CHEMICAL NAME :
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Sodium thiosulfate, pentahydrate
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CAS REGISTRY NUMBER :
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10102-17-7
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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7
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MOLECULAR FORMULA :
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O3-S2.2Na.5H2-O
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MOLECULAR WEIGHT :
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317.17
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WISWESSER LINE NOTATION :
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NA2 S2-O-Q2 QH5
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human
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DOSE/DURATION :
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300 mg/kg/7D
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - cyanosis
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REFERENCE :
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TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920- Volume(issue)/page/year: 63,383,1956
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>2500 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 31,959,1980
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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5600 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,1713,1981
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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2350 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,89,1979
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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3 gm/kg
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TOXIC EFFECTS :
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Cardiac - pulse rate increase, without fall in BP Vascular - BP elevation not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory stimulation
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REFERENCE :
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CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 50,255,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1294 No. of Facilities: 358 (estimated) No. of Industries: 10 No. of Occupations: 12 No. of Employees: 3894 (estimated) No. of Female Employees: 2457 (estimated)
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