51963-61-2
51963-61-2 structure
- Name: ATP disodium trihydrate
- Chemical Name: Adenosine Disodium Triphosphate
- CAS Number: 51963-61-2
- Molecular Formula: C10H14N5Na2O13P3
- Molecular Weight: 551.145
- Catalog: Biochemical Nucleoside drugs Nucleotides and their analogues
- Create Date: 2018-03-05 08:00:00
- Modify Date: 2024-01-12 00:18:29
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ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation[1][2].
| Name | Adenosine Disodium Triphosphate |
|---|---|
| Synonyms |
EINECS 213-579-1
adenosine-5'-triphosphate disodium trihydrate 9H-Purin-6-amine, 9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]pentofuranosyl]-, sodium salt (1:2) disodium adenosine 5'-triphosphate trihydrate Disodium 9-[5-O-(hydroxy{[hydroxy(phosphonatooxy)phosphoryl]oxy}phosphoryl)pentofuranosyl]-9H-purin-6-amine Adenosine-5'-triphosphate disodium salt hydrate,water ADENOSINE-5'-TRIPHOSPHATE DISODIUM SALT HYDR.,CALCIUM FREE 5'-ATP-Na2 MFCD00067316 Adenosine 5'-triphosphate disodium salt |
| Description | ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | ATP disodium trihydrate (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3]. ATP disodium trihydrate (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4]. ATP disodium trihydrate stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4]. |
| In Vivo | ATP disodium trihydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4]. ATP disodium trihydrate induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4]. Animal Model: Four-week-old Kunming mice (18-22 g)[4] Dosage: 50 mg/kg Administration: Intraperitoneal injection, before bacterial (E. coli) challenge Result: Protected mice from bacterial infection. |
| References |
| Melting Point | 176ºC |
|---|---|
| Molecular Formula | C10H14N5Na2O13P3 |
| Molecular Weight | 551.145 |
| Exact Mass | 550.959656 |
| PSA | 314.22000 |
| Appearance | lyophilized powder |
| Storage condition | −20°C |
| Water Solubility | H2O: 50 mg/mL |
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | 36/37/38 |
| Safety Phrases | S22-S24/25-S36-S26 |
| WGK Germany | 3 |
| RTECS | AU7417000 |