52886-36-9

52886-36-9 structure

Name: Cholic acid-13C
Chemical Name: cholic acid-24-13c
CAS Number: 52886-36-9
Molecular Formula: C₂₄H₄₀O₅
Molecular Weight: 409.564
Create Date: 2018-05-12 08:00:00
Modify Date: 2024-01-02 22:56:45
Cholic acid-13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

Name	cholic acid-24-13c
Synonyms	<24-13C>-Cholsaeure <24-13C>-Chenodeoxycholsaeure (3α,5β,7α,12β)-3,7,12-Trihydroxy(24-C)cholan-24-oic acid Cholan-24-oic-24-C acid, 3,7,12-trihydroxy-, (3α,5β,7α,12β)- Cholan-24-oic-24-C acid, 3,7,12-trihydroxy-, (3α,5β,7α,12α)- (3α,5β,7α,12α)-3,7,12-Trihydroxy(24-C)cholan-24-oic acid

Description	Cholic acid-13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684. [3]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45(4):346-352.