7325-16-8

7325-16-8 structure
7325-16-8 structure
  • Name: Glycerol-d3
  • Chemical Name: 1,2,3-trideuteriooxypropane
  • CAS Number: 7325-16-8
  • Molecular Formula: C3H5D3O3
  • Molecular Weight: 95.11230
  • Create Date: 2018-05-15 08:00:00
  • Modify Date: 2024-01-02 12:05:10
  • Glycerol-d3 is the deuterium labeled Glycerol[1]. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[2][3][4].

Name 1,2,3-trideuteriooxypropane
Synonyms Tri-O-deuterio-glycerin
MFCD00064295
Tris-O-deutero-propan-1,2,3-triol
O-Trideuterio-glycerin
glycerol-OD3
O,O',O''-trideuterio-propane-1,2,3-triol
glycer(ol-d3)
Description Glycerol-d3 is the deuterium labeled Glycerol[1]. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[2][3][4].
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Pennings S, et al. Effect of glycerol on the separation of nucleosomes and bent DNA in low ionic strengthpolyacrylamide gel electrophoresis. Nucleic Acids Res. 1992 Dec 25;20(24):6667-72.  

[3]. Yazdani SS, et al. Anaerobic fermentation of glycerol: a path to economic viability for the biofuelsindustry. Curr Opin Biotechnol. 2007 Jun18(3):213-9.  

[4]. Huang ZH, et al. Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure. Eur J Pharmacol. 2000 Oct 20406(3):453-60.  

Density 1.302 g/mL at 25ºC
Boiling Point 182ºC(lit.)
Melting Point 20ºC(lit.)
Molecular Formula C3H5D3O3
Molecular Weight 95.11230
Flash Point >230 °F
Exact Mass 95.06620
PSA 60.69000
Index of Refraction n20/D 1.4676(lit.)
RIDADR NONH for all modes of transport
Precursor  2

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