660846-41-3

660846-41-3 structure

Name: GW542573X
Chemical Name: 2-Methyl-2-propanyl 4-({[(2-methoxyphenyl)carbamoyl]oxy}methyl)-1 -piperidinecarboxylate
CAS Number: 660846-41-3
Molecular Formula: C₁₉H₂₈N₂O₅
Molecular Weight: 364.44
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2017-03-21 00:56:10
Modify Date: 2024-01-02 12:25:03
GW542573X is a potent and selective Ca2+-activated K+ 2 (SK2) channels activator. GW542573X induces the Ca2+-response curve of hSK1 that left-shifted from an EC50 (Ca2+) value of 410 nM to 240 nM[1].

Name	2-Methyl-2-propanyl 4-({[(2-methoxyphenyl)carbamoyl]oxy}methyl)-1 -piperidinecarboxylate
Synonyms	DAU 5884 hydrochloride

Description	GW542573X is a potent and selective Ca2+-activated K+ 2 (SK2) channels activator. GW542573X induces the Ca2+-response curve of hSK1 that left-shifted from an EC50 (Ca2+) value of 410 nM to 240 nM[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Hougaard C, et, al. Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment. Mol Pharmacol. 2009 Sep;76(3):569-78.