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57746-15-3

57746-15-3 structure
57746-15-3 structure
  • Name: L-(2,6-2H2)Tyrosine
  • Chemical Name: (2S)-2-amino-3-(2,6-dideuterio-4-hydroxyphenyl)propanoic acid
  • CAS Number: 57746-15-3
  • Molecular Formula: C9H9D2NO3
  • Molecular Weight: 183.201
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2018-12-27 22:17:23
  • Modify Date: 2024-01-08 16:25:09
  • L-Tyrosine-d2-2 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
Name (2S)-2-amino-3-(2,6-dideuterio-4-hydroxyphenyl)propanoic acid
Synonyms [2',6'-2H2]-L-tyrosine
L-(2,6-H)Tyrosine
L-Tyrosine-2,6-d2
L-4-Hydroxyphenyl-2,6-d2-alanine
L-Tyrosine-d2 (phenyl-2,6-d2)
L-Tyrosine-2,6-d
MFCD00190464
Description L-Tyrosine-d2-2 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.

[3]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.

[4]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.

[5]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.

[6]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.

[7]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.

[8]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.

[9]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.

[10]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.

[11]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.

[12]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.

[13]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.
Density 1.3±0.1 g/cm3
Boiling Point 385.2±32.0 °C at 760 mmHg
Melting Point >300ºC (dec.)(lit.)
Molecular Formula C9H9D2NO3
Molecular Weight 183.201
Flash Point 186.7±25.1 °C
Exact Mass 183.086441
PSA 83.55000
LogP 0.38
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.614
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
Precursor  2

DownStream  0


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title: CAS No. 57746-15-3 | Chemsrc address: https://www.chemsrc.com/en/baike/687880.html

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