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Related CAS#:
151-67-7 754-19-8
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151-67-7

151-67-7 structure
151-67-7 structure
Name halothane
Synonyms Halotan
Phthorothanum
Ftorotan
1,1,1-trifluoro-2-chloro-2-bromoethane
Fluothane
Bromochlorotrifluoroethane
MFCD00009602
Narcotan
EINECS 205-796-5
R 123B1
1-bromo-1-chloro-2,2,2-trifluoroethane
BrCH(Cl)CF3
2-bromo-2-chloro-1,1,1-trifluoroethane
Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-
Narcotane
2-Chloro-2-bromo-1,1,1-trifluoroethane
(±)-Halothane
1,1,1-trifluoro-chlorobromoethane
Rhodialothan
Density 1.9±0.1 g/cm3
Boiling Point 53.4±8.0 °C at 760 mmHg
Molecular Formula C2HBrClF3
Molecular Weight 197.382
Flash Point -13.9±18.4 °C
Exact Mass 195.890213
LogP 2.30
Vapour Pressure 268.8±0.1 mmHg at 25°C
Index of Refraction 1.389
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KH6550000
CHEMICAL NAME :
Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-
CAS REGISTRY NUMBER :
151-67-7
BEILSTEIN REFERENCE NO. :
1736947
LAST UPDATED :
199712
DATA ITEMS CITED :
74
MOLECULAR FORMULA :
C2-H-Br-Cl-F3
MOLECULAR WEIGHT :
197.39
WISWESSER LINE NOTATION :
GYEXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
7000 ppm/3H
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - body temperature increase
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
129 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Cardiac - change in rate Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5680 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - antipsychotic
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
29000 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
98 gm/m3/2H
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Liver - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - antipsychotic
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10000 ppm/1H/7D-I
TOXIC EFFECTS :
Liver - other changes Nutritional and Gross Metabolic - conditioned vitamin deficiency
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 ppm/24H/5W-C
TOXIC EFFECTS :
Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 ppm/8H/8W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Kidney, Ureter, Bladder - urine volume increased Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5126 mg/m3/4H/17W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 ppm/6H/9D-I
TOXIC EFFECTS :
Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 ppm/24H/5W-C
TOXIC EFFECTS :
Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1 pph/4H/80D-I
TOXIC EFFECTS :
Liver - other changes Immunological Including Allergic - increase in cellular immune response Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
50 ppm/24H/5W-C
TOXIC EFFECTS :
Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
10000 ppm/1H/7D-I
TOXIC EFFECTS :
Liver - other changes Nutritional and Gross Metabolic - conditioned vitamin deficiency Biochemical - Effect on specific coenzyme - not otherwise specified
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
100 ppm/8H
SEX/DURATION :
female 2-22 day(s) after conception lactating female 30 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
8000 ppm/12H
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
1600 ppm/8H
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
10 ppm/8H
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
8000 ppm/6H
SEX/DURATION :
female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
10 ppm/8H
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
3000 ppm/4H
SEX/DURATION :
female 9 week(s) pre-mating female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - other measures of fertility
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
1000 ppm/4H
SEX/DURATION :
female 9 week(s) pre-mating female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
1 pph/3H
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
3000 ppm/4H
SEX/DURATION :
female 9 week(s) pre-mating female 1-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
14000 ppm/1H
SEX/DURATION :
female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
DNA inhibition

MUTATION DATA

TEST SYSTEM :
Bird - chicken
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 12,366,1976 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 404 mg/m3 (50 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,93,1987 TOXICOLOGY REVIEW ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976- Volume(issue)/page/year: 16,67,1976 TOXICOLOGY REVIEW INTEAG Internist. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1960- Volume(issue)/page/year: 15,7,1974 TOXICOLOGY REVIEW ARMCAH Annual Review of Medicine. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.1- 1950- Volume(issue)/page/year: 25,411,1974 TOXICOLOGY REVIEW CJSUAX Canadian Journal of Surgery. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1957- Volume(issue)/page/year: 15,217,1972 TOXICOLOGY REVIEW AASXAP Acta Anaesthesiologica Scandinavica, Supplementum. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1959- Volume(issue)/page/year: 49,1,1971 TOXICOLOGY REVIEW AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 57,328,1978 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.5 ppm (4.1 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-BELGIUM:TWA 50 ppm (404 mg/m3) JAN 1993 OEL-DENMARK:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-FINLAND:TWA 1 ppm (8 mg/m3);STEL 3 ppm (24 mg/m3) JAN 1993 OEL-GERMANY:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-HUNGARY:TWA 30 mg/m3;STEL 60 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-RUSSIA:STEL 20 mg/m3 JAN 1993 OEL-SWEDEN:TWA 5 ppm (40 mg/m3);STEL 10 ppm (80 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (40 mg/m3);STEL 10 ppm (80 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HALOTHANE-air:CL 2 ppm/60M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82943 No. of Facilities: 806 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 9490 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82943 No. of Facilities: 4118 (estimated) No. of Industries: 3 No. of Occupations: 15 No. of Employees: 94682 (estimated) No. of Female Employees: 76108 (estimated)
Symbol GHS05 GHS07 GHS08
GHS05, GHS07, GHS08
Signal Word Danger
Hazard Statements H315-H318-H335-H360
Precautionary Statements P201-P261-P280-P305 + P351 + P338-P308 + P313
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
Hazard Codes T,Xi,Xn
Risk Phrases R36
Safety Phrases S53-S23-S26-S36/37-S45-S36
RIDADR UN 3334
WGK Germany 3
RTECS KH6550000
HS Code 2903799090
754-17-6 structure

754-17-6

~83%

151-67-7 structure

151-67-7

Literature: Hu, Chang-Ming; Tu, Ming-Hu Journal of Fluorine Chemistry, 1991 , vol. 55, # 1 p. 101 - 104
359-08-0 structure

359-08-0

~%

151-67-7 structure

151-67-7

84011-25-6 structure

84011-25-6

Literature: Journal of Organic Chemistry, , vol. 48, # 2 p. 242 - 250
421-06-7 structure

421-06-7

~%

151-67-7 structure

151-67-7

Literature: US2849502 , ; DE1018853 , ;
75-88-7 structure

75-88-7

~%

151-67-7 structure

151-67-7

Literature: US2849502 , ; DE1018853 , ;
359-08-0 structure

359-08-0

22082-78-6 structure

22082-78-6

~%

151-67-7 structure

151-67-7

84011-25-6 structure

84011-25-6

Literature: Journal of Organic Chemistry, , vol. 48, # 2 p. 242 - 250
306-83-2 structure

306-83-2

~%

151-67-7 structure

151-67-7

Literature: Journal of the Chemical Society, , p. 387,395
306-83-2 structure

306-83-2

7726-95-6 structure

7726-95-6

~%

7647-01-0 structure

7647-01-0

151-67-7 structure

151-67-7

Detail
Literature: Journal of the Chemical Society, , p. 387,395
HS Code 2903799090
Summary 2903799090 halogenated derivatives of acyclic hydrocarbons containing two or more different halogens。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Chemsrc provides CAS#:151-67-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 151-67-7 | Chemsrc address: https://www.chemsrc.com/en/baike/722826.html

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