103051-26-9

103051-26-9 structure

Name: B 746
Chemical Name: N,5-bis(4-chlorophenyl)-3-ethyliminophenazin-2-amine
CAS Number: 103051-26-9
Molecular Formula: C₂₆H₂₀Cl₂N₄
Molecular Weight: 459.37
Create Date: 2016-05-16 23:33:07
Modify Date: 2024-01-13 09:43:15
B746 is a clofazimine analog with anti-Mycobacterium avium complex (MAC) activity and is less effective when used with clofazimine or streptomycin[1].

Name	N,5-bis(4-chlorophenyl)-3-ethyliminophenazin-2-amine
Synonyms	3-Aethylamino-2-(4-chlor-anilino)-5-(4-chlor-phenyl)-phenazinium-betain CF Deriv B746 3-p-Chloroanilino-10-(p-chlorophenyl)-2-(ethylimino)-2,10-dihydrophenazine B 746 3-ethylamino-2-(4-chloro-anilino)-5-(4-chloro-phenyl)-phenazinium-betaine

Description	B746 is a clofazimine analog with anti-Mycobacterium avium complex (MAC) activity and is less effective when used with clofazimine or streptomycin[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	B746（1、3、10 μM；7 天）显著抑制分枝杆菌的生长[1]。
In Vivo	B746 （口服；10、20、30 mg/kg；单剂量；第一天和第 2、4 和 6 周）抑制米色小鼠脾脏中的分枝杆菌生长[1]。 Animal Model: beige mice Dosage: 10, 20, 30 mg/kg Administration: p.o.; 10, 20, 30 mg/kg; single dose; first day and 2, 4 and 6 week after infection Result: Reduced Colony Forming Units (CFU) counts of Mycobacteria in spleen of beige mice.
References	[1]. Gangadharam PR, et al. In vitro, in vivo, and intracellular chemotherapeutic activity of B746, a clofazimine analogue against Mycobacterium avium complex. Tuber Lung Dis. 1992 Aug;73(4):192-9.