Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Swertiamarin
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BioBioPha
China
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Swertiamarin
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Chengdu Pukang Biotechnology Co., Ltd.
China
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DC Chemicals Limited
China
Product Name: Swertiamarine
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17388-39-5

17388-39-5 structure

17388-39-5 structure

Name: Swertiamarin
Chemical Name: Swertiamarine
CAS Number: 17388-39-5
Molecular Formula: C₁₆H₂₂O₁₀
Molecular Weight: 374.340
Catalog: API Digestive system medication Gastrointestinal expectorant
Create Date: 2018-03-12 08:00:00
Modify Date: 2024-01-02 10:33:36
Swertiamarin, a secoiridoid glycoside found in genera of Enicostemma Species, confers anti-hyperglycemic and anti-hyperlipidemic effects[1].

Name	Swertiamarine
Synonyms	MFCD07783984 (4aR,5R,6S)-5-ethenyl-4a-hydroxy-1-oxo-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-6-yl β-D-glucopyranoside 1H,3H-Pyrano[3,4-c]pyran-1-one, 5-ethenyl-6-(β-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-, (4aR,5R,6S)- (4aR,5R,6S)-4a-Hydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-5-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one (4aR,5R,6S)-5-Ethenyl-4a-hydroxy-1-oxo-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyr-6-yl-β-D-glucopyranoside 4,4a,5,6-Tetrahydro-4aa-hydroxy-1-oxo-5b-vinyl-1H,3H-pyrano[3,4-c]pyran-6-yl b-D-Glucopyranoside (4aR,5R,6S)-4a-Hydroxy-1-oxo-5-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-6-yl β-D-glucopyranoside 1H,3H-Pyrano(3,4-c)pyran-1-one, 5-ethenyl-6-(β-d-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-, (4aR,5R,6S)- Swertiamarin [4aR-(4aa,5b,6a)]-5-Ethenyl-6-(b-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-1H,3H-pyrano[3,4-c]pyran-1-one

Description	Swertiamarin, a secoiridoid glycoside found in genera of Enicostemma Species, confers anti-hyperglycemic and anti-hyperlipidemic effects[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Patel N, et al. Curr Drug Targets. 2018;19(16):1958-1967. doi: 10.2174/1389450119666180406113428.

Density	1.6±0.1 g/cm3
Boiling Point	649.3±55.0 °C at 760 mmHg
Melting Point	111ºC
Molecular Formula	C₁₆H₂₂O₁₀
Molecular Weight	374.340
Flash Point	237.7±25.0 °C
Exact Mass	374.121307
PSA	155.14000
LogP	-3.15
Vapour Pressure	0.0±4.4 mmHg at 25°C
Index of Refraction	1.626
Storage condition	?20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ1366700

CHEMICAL NAME :: 1H,3H-Pyrano(3,4-c)pyran-1-one, 4,4a,5,6-tetrahydro-5-ethenyl-6-(beta-d-glucopyranosy loxy)-4a-hydroxy-, (4aR-(4a-alpha,5-beta,6-alpha))-

CAS REGISTRY NUMBER :: 17388-39-5

BEILSTEIN REFERENCE NO. :: 0055278

LAST UPDATED :: 199806

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H22-O10

MOLECULAR WEIGHT :: 374.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,464,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,464,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,464,1982

Hazard Codes	C
Risk Phrases	R23:Toxic by inhalation. R34:Causes burns.
Safety Phrases	S26-S36-S45
RIDADR	UN 1789
WGK Germany	3.0
RTECS	UQ1366700
Packaging Group	III
Hazard Class	8