3233-32-7

3233-32-7 structure

Name: 4-Acetoxyphenol
Chemical Name: 4-hydroxyphenyl acetate
CAS Number: 3233-32-7
Molecular Formula: C₈H₈O₃
Molecular Weight: 152.14700
Catalog: Research Areas Others
Create Date: 2018-03-14 08:00:00
Modify Date: 2024-01-05 17:30:14
4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor[1].

Name	4-hydroxyphenyl acetate
Synonyms	p-acetoxyphenol p-hydroxyphenyl acetate 4-Acetoxyphenol 1,4-Benzenediol,monoacetate (4-hydroxyphenyl) acetate hydroquinone acetate 4-hydroxyphenylacetat 4-Hydroxyphenyl acetate hydroquinone monoacetate

Description	4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor[1].
Related Catalog	Research Areas >> Others
Target	Human Endogenous Metabolite
In Vitro	4-Hydroxyphenyl acetate (5 μM; 24 h) protects retinal pigment epithelial (RPE) cells from oxidative stress-induced cell death[1]. 4-Hydroxyphenyl acetate (5 μM; 24 h; ARPE-19 cells) inhibits the increase of ROS in response to oxidative stress and up-regulated the expression of cytoprotective genes including NQO1 and HO-1 genes[1]. Cell Viability Assay[1] Cell Line: ARPE-19 cells Concentration: 5 μM Incubation Time: 24 hours Result: Protected up to 89%, 92%, and 90% of ARPE-19 cells exposed to 100, 200, and 300 μM tBHP, respectively.

Hazard Codes	Xi