CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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US5908290
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CHEMICAL NAME :
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3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-(2-(bis(4-(trifluoromethyl)pheny l)methoxy) ethyl)-, hydrochloride
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CAS REGISTRY NUMBER :
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110283-66-4
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LAST UPDATED :
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199403
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DATA ITEMS CITED :
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4
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MOLECULAR FORMULA :
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C23-H21-F6-N-O3.Cl-H
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MOLECULAR WEIGHT :
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509.91
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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894 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - lacrimation Behavioral - coma Gastrointestinal - hypermotility, diarrhea
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REFERENCE :
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DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 28,65,1993
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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703 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - other changes
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REFERENCE :
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DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 28,65,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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14 gm/kg/4W-C
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TOXIC EFFECTS :
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Behavioral - food intake (animal) Endocrine - hyperglycemia Related to Chronic Data - death
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REFERENCE :
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DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 28,65,1993
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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420 mg/kg/4W-I
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - ataxia
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REFERENCE :
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DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 28,65,1993
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