CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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KR9460000
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CHEMICAL NAME :
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Ethylamine, 2,2'-oxybis(N,N-dimethyl-
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CAS REGISTRY NUMBER :
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3033-62-3
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BEILSTEIN REFERENCE NO. :
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1739668
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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19
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MOLECULAR FORMULA :
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C8-H20-N2-O
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MOLECULAR WEIGHT :
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160.30
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WISWESSER LINE NOTATION :
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1N1&2 2O
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,721,1986
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TYPE OF TEST :
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Open irritation test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/27/1971
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 5,3,1986
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/27/1971
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,721,1986 ** ACUTE TOXICITY DATA **
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1070 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 5,3,1986
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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117 ppm/6H
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - corneal damage Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes
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REFERENCE :
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NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536387
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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280 uL/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1540 mg/kg/7D-I
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536157
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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20 ppm/6H/9D-I
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - ptosis Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536526
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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292 mg/kg/11D-I
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 5,3,1986
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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391 mg/kg/13W-I
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TOXIC EFFECTS :
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Skin and Appendages - dermatitis, other (after systemic exposure)
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REFERENCE :
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JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 5,3,1986 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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DOSE :
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650 mg/kg
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SEX/DURATION :
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female 6-18 day(s) after conception
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REFERENCE :
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JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 5,263,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BIS(2-(DIMETHYlAMINO)ETHYL)ETHER-air:minimize exposure REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0015 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 40 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0015 No. of Facilities: 60 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1529 (estimated) No. of Female Employees: 165 (estimated)
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