Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride
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64000-73-3

64000-73-3 structure

Name: 3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride
Chemical Name: 1-[(6-Hydrazino-3-pyridazinyl)(methyl)amino]-2-propanol
CAS Number: 64000-73-3
Molecular Formula: C₈H₁₅N₅O
Molecular Weight: 197.23800
Catalog: Research Areas Cardiovascular Disease
Create Date: 2016-06-17 19:50:17
Modify Date: 2024-09-29 02:18:44
Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model[1][2].

Name	1-[(6-Hydrazino-3-pyridazinyl)(methyl)amino]-2-propanol
Synonyms	DESME propildazine Propyldazine TRUST radar FORDO orbit Dadar TILT JUNO desmel

Description	Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vivo	Pildralazine (6-43 mg/kg; p.o.; once daily) shows no significant carcinogenicity in B6C3F1 and BALB/c mice under a long-term bioassay and a transplacental-infantile bioassay[1]. Pildralazine and Hydralazine (HY-B0464A) act on a common receptor,sensitive to endogenous ATP and adenosine in the isolated tail artery from normotensive Wistar (NW) rats[2]. Pildralazine (1 mg/kg; p.o.; ) significantly inhibits the onset of severe hypertension in spontaneously hypertensive rats (SHR) model[3]. Animal Model: Male and female B6C3F1 and to female BALB/c mice (8 weeks old)[1] Dosage: 100, 200, and 400 ppm dose: 8, 20, and 40 mg/kg/day in B6C3F1 males, 8, 22, and 43 mg/kg/day in B6C3F1 females, and 6, 15, and 34 mg/kg/day in BALB/c females, respectively Administration: Oral gavage; added in the drinking water; provided for 80 weeks, and observed for 130-133 weeks age Result: Resulted over 80% of mice alive beyond 78 weeks of age.

CHEMICAL NAME :: 3(2H)-Pyridazinone, 6-((2-hydroxypropyl)methylamino)-, hydrazone

REFERENCE :: TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 5,339,1985

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%