1197-21-3

1197-21-3 structure
1197-21-3 structure

Name phentermine hydrochloride
Synonyms MFCD00058289
2-methyl-1-phenylpropan-2-amine,hydrochloride
Phentermine Hydrochloride
EINECS 214-821-9
Boiling Point 206ºC at 760mmHg
Melting Point 200-201℃
Molecular Formula C10H16ClN
Molecular Weight 185.69400
Flash Point 93.1ºC
Exact Mass 185.09700
PSA 26.02000
LogP 3.46870
Vapour Pressure 0.243mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SH4950000
CHEMICAL NAME :
Phenethylamine, alpha,alpha-dimethyl-, hydrochloride
CAS REGISTRY NUMBER :
1197-21-3
LAST UPDATED :
199707
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H15-N.Cl-H
MOLECULAR WEIGHT :
185.72
WISWESSER LINE NOTATION :
ZX1&1&1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
188 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,256,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
81 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 17,121,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
154 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,256,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,187,1943
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements Missing Phrase - N15.00950417
Hazard Codes T: Toxic;Xi: Irritant;
Risk Phrases R25
Safety Phrases S22-S26-S36/37-S45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS SH4950000
HS Code 2921499090

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Literature: WO2010/59658 A1, ; Page/Page column 158 ; WO 2010/059658 A1

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Literature: US2006/69110 A1, ; Page/Page column 16 ; US 20060069110 A1

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Literature: Journal of the Chemical Society, Chemical Communications, , # 2 p. 176 - 178

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Literature: Tetrahedron Letters, , vol. 26, # 9 p. 1245 - 1248

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Literature: Synthesis, , # 5 p. 487 - 489

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Literature: Synthesis, , # 5 p. 487 - 489

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Literature: Tetrahedron, , vol. 36, p. 1753 - 1756

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1197-21-3 structure

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Literature: Tetrahedron, , vol. 36, p. 1753 - 1756

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1197-21-3 structure

1197-21-3

Literature: Tetrahedron, , vol. 36, p. 1753 - 1756
HS Code 2921499090
Summary 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%