50597-93-8

50597-93-8 structure

Name: Isojacareubin
Chemical Name: 6,10,11-trihydroxy-3,3-dimethyl-3H,7H-pyrano[2,3-c]xanthen-7-one
CAS Number: 50597-93-8
Molecular Formula: C₁₈H₁₄O₆
Molecular Weight: 326.30
Catalog: Natural product Xanthone
Create Date: 2017-02-15 02:37:24
Modify Date: 2024-01-09 12:09:38
Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis[1][2][3].

Name	6,10,11-trihydroxy-3,3-dimethyl-3H,7H-pyrano[2,3-c]xanthen-7-one
Synonyms	6,10,11-Trihydroxy-3,3-dimethyl-3H,7H-pyrano[2,3-c]xanthen-7-one 3H,7H-Pyrano[2,3-c]xanthen-7-one, 6,10,11-trihydroxy-3,3-dimethyl-

Description	Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis[1][2][3].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Anti-infection >> SARS-CoV Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Kyoko Ishiguro, et al. An isopentenylated flavonol from Hypericum japonicum. Phytochemistry. 1993. 32 (6), 1583-1585. [2]. Khan A, et al. Discovery of Isojacareubin as a covalent inhibitor of SARS-CoV-2 main protease using structural and experimental approaches. J Med Virol. 2023 Feb;95(2):e28542. [3]. Yuan X, et al. Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo. Sci Rep. 2015 Aug 6;5:12889.

Hazard Codes	Xi