Name | 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine |
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Synonyms |
UNII-M3EFS94984
5-((4,5-Dimethoxy-2-methylphenyl)methyl)-2,4-pyrimidinediamine Ro 5-9754 component of Rofenaid Ormetoprim EINECS 230-246-6 MFCD00057747 2,4-Pyrimidinediamine, 5-[(4,5-dimethoxy-2-methylphenyl)methyl]- 5-(4,5-Dimethoxy-2-methylbenzyl)-2,4(1H,3H)-pyrimidinediimine 5-(4,5-Dimethoxy-2-methylbenzyl)pyrimidine-2,4-diamine 2,4(1H,3H)-Pyrimidinediimine, 5-[(4,5-dimethoxy-2-methylphenyl)methyl]- 5-(4,5-Dimethoxy-2-methylbenzyl)-2,4-pyrimidinediamine Ormethoprim Ormetorprim |
Description | Ormetoprim is a veterinary antimicrobial which commonly used in aquaculture and poultry industries. Ormetoprim can be used to prevent the spread of disease in freshwater aquaculture and promote growth in farm animals[1][2]. |
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Related Catalog | |
In Vivo | Ormetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and Cmax (1.2±0.2 μg/mL)[3]. Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), Cmax (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration[3]. Animal Model: Hybrid striped bass (565-805 g)[3] Dosage: 50 mg/kg Sulfadimethoxine and Ormetoprim in a 5:1 ratio (Pharmacokinetic Analysis) Administration: I.p. and p.o. administration Result: I.p.: t1/2(elim)=7.5 h; t1/2(abs)=5.4 h; Cmax=1.2 μg/mL. P.o.: t1/2(elim)=3.9 h; t1/2(abs)=3.9 h; Cmax=1.6 μg/mL; F=78.5%. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 398.2±52.0 °C at 760 mmHg |
Melting Point | 233°C |
Molecular Formula | C14H18N4O2 |
Molecular Weight | 274.318 |
Flash Point | 194.6±30.7 °C |
Exact Mass | 274.142975 |
PSA | 96.28000 |
LogP | 1.13 |
Vapour Pressure | 0.0±0.9 mmHg at 25°C |
Index of Refraction | 1.608 |
Storage condition | 0-6°C |
~% 6981-18-6 |
Literature: US2007/49609 A1, ; Page/Page column 83 ; US 20070049609 A1 |
~% 6981-18-6 |
Literature: US2005/209260 A1, ; Page/Page column 89 ; |
~60% 6981-18-6 |
Literature: Manchand, Percy S.; Rosen, Perry; Belica, Peter S.; Oliva, Gloria V.; Perrotta, Agostino V.; Wong, Harry S. Journal of Organic Chemistry, 1992 , vol. 57, # 13 p. 3531 - 3535 |
~% 6981-18-6 |
Literature: Journal of Organic Chemistry, , vol. 57, # 13 p. 3531 - 3535 |
~% 6981-18-6 |
Literature: Journal of Organic Chemistry, , vol. 57, # 13 p. 3531 - 3535 |
~% 6981-18-6 |
Literature: Journal of Organic Chemistry, , vol. 57, # 13 p. 3531 - 3535 |
~% 6981-18-6 |
Literature: Journal of Organic Chemistry, , vol. 57, # 13 p. 3531 - 3535 |
~% 6981-18-6 |
Literature: Journal of Organic Chemistry, , vol. 57, # 13 p. 3531 - 3535 |
Precursor 10 | |
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DownStream 0 |