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3522-50-7

3522-50-7 structure
3522-50-7 structure
  • Name: Ferric Citrate
  • Chemical Name: Iron(III) citrate
  • CAS Number: 3522-50-7
  • Molecular Formula: C6H5FeO7
  • Molecular Weight: 244.945
  • Catalog: Organic raw materials Organometallic salt
  • Create Date: 2018-06-26 10:30:04
  • Modify Date: 2024-01-02 01:14:21
  • Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research.
Name Iron(III) citrate
Synonyms Citric acid iron
MFCD00013098
Iron citrate
Citric acid, iron salt
Iron(3+) citrate
EINECS 219-045-4
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, iron (3+) salt (1:1)
Iron(iii) citrate
Citric acid, iron (3+) salt (1:1)
Ferric citrate
EFRRIC CITRATE
Einecs 222-536-6
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, iron(3+) salt (1:1)
Citric acid iron(III) salt
Iron(III)citrate
Description Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research.
Related Catalog
In Vitro Ferric citrate (Iron(III) citrate; 1 mM; 24 hours) significantly induces CM cell death[1]. Ferric citrate (Iron(III) citrate; 0.1 mM, 1 mM, 2 mM; 24 hours) increases ROS generation in cardiomyocyte (CM) cells in a dose-dependent manner[1]. Cell Viability Assay[1] Cell Line: Cardiomyocyte (CM) cells Concentration: 1 mM Incubation Time: 24 hours Result: Significantly induced CM cell death.
In Vivo Here we compared the effects of Ferric citrate (25 μg/g) administration versus a mineral sufficient control diet using the Col4a3 knockout mouse model of progressive CKD and age-matched wild-type mice. Ferric citrate is given to knockout mice for four weeks beginning at six weeks of age when they had overt chronic kidney disease (CKD), or for six weeks beginning at four weeks of age when they had early CKD. Ferric citrate rescues iron deficiency and anemia in knockout mice regardless of the timing of treatment initiation, and circulating levels and bone expression of FGF23 are reduced. Ferric citrate also improves cardiac function and significantly improves survival[3]. Ferric citrate is an efficacious and safe phosphate binder that increases iron stores and reduces intravenous iron and erythropoietin-stimulating agent use while maintaining hemoglobin. Ferric citrate can increase transferrin saturation, serum ferritin, and hemoglobin[2].
References

[1]. Yuichi Baba, et al. Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H659-H668.

[2]. Julia B Lewis, et al. Ferric citrate controls phosphorus and delivers iron in patients on dialysis. J Am Soc Nephrol. 2015 Feb;26(2):493-503.

[3]. Connor Francis, et al. Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease. Kidney Int. 2019 Dec;96(6):1346-1358.
Density 1.762g/cm3
Boiling Point 309.6ºC at 760 mmHg
Molecular Formula C6H5FeO7
Molecular Weight 244.945
Flash Point 155.2ºC
Exact Mass 244.938477
PSA 140.62000
Vapour Pressure 5.73E-05mmHg at 25°C
Index of Refraction 1.575
Storage condition Store at RT.
Stability Stable. Incompatible with strong oxidizing agents.
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2918150000
HS Code 2918150000
Summary 2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%

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title: CAS No. 3522-50-7 | Chemsrc address: https://www.chemsrc.com/en/baike/829362.html

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