15686-83-6

15686-83-6 structure

Name: pyrante
Chemical Name: pyrantel
CAS Number: 15686-83-6
Molecular Formula: C₃₄H₃₀N₂O₆S
Molecular Weight: 594.67700
Catalog: API Antiparasitic drug Anthelmintic
Create Date: 2018-07-29 11:42:20
Modify Date: 2024-01-11 19:44:35
Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2].

Name	pyrantel
Synonyms	pyrante banminth Pyrantel Base 1,4,5,6-Tetrahydro-1-methyl-2-[(E)-2-(2-thienyl)vinyl]pyrimidine PYRANTEL PARMOATE strongid pyrequan 4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)-(e)-pyrimidin 1-methyl-2-(2-thiophen-2-ylvinyl)-1,4,5,6-tetrahydro-pyrimidine PYRANTELUM 1-methyl-2-(trans-2-thiophen-2-yl-vinyl)-1,4,5,6-tetrahydro-pyrimidine

Description	Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR
Target	Parasites[1][2].
In Vitro	Pyrantel (10 nM-10 µM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity[1][2]. Cell Viability Assay[1] Cell Line: A. suum Concentration: 10 nM-10 µM Incubation Time: 72 h Result: Inhibited A. suum with a pEC50 value of 7.24. Cell Viability Assay[2] Cell Line: N. americanus Concentration: 0-168.2 M (0-100 µg/mL) Incubation Time: 72 h Result: Inhibited third-stage larvae and adult of N. americanus with IC50 values of 2.0 and 7.6 mg/mL, respectively.
In Vivo	Pyrantel (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%[2]. Animal Model: Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected)[2]. Dosage: 10 mg/kg Administration: Oral administration; single. Result: Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.

CHEMICAL NAME :: Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)-, (E)-

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANBCB3 Antibiotics and Chemotherapy (Basel). (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.17- 1971- Volume(issue)/page/year: 30,1,1981

HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%