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  • DC Chemicals Limited
  • China
  • Product Name: Pyrantel
  • Price: ¥Inquiry/100mg ¥Inquiry/250mg ¥Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Tony Cao

15686-83-6

15686-83-6 structure
15686-83-6 structure
  • Name: pyrante
  • Chemical Name: pyrantel
  • CAS Number: 15686-83-6
  • Molecular Formula: C34H30N2O6S
  • Molecular Weight: 594.67700
  • Catalog: API Antiparasitic drug Anthelmintic
  • Create Date: 2018-07-29 11:42:20
  • Modify Date: 2024-01-11 19:44:35
  • Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2].

Name pyrantel
Synonyms pyrante
banminth
Pyrantel Base
1,4,5,6-Tetrahydro-1-methyl-2-[(E)-2-(2-thienyl)vinyl]pyrimidine
PYRANTEL PARMOATE
strongid
pyrequan
4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)-(e)-pyrimidin
1-methyl-2-(2-thiophen-2-ylvinyl)-1,4,5,6-tetrahydro-pyrimidine
PYRANTELUM
1-methyl-2-(trans-2-thiophen-2-yl-vinyl)-1,4,5,6-tetrahydro-pyrimidine
Description Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2].
Related Catalog
Target

Parasites[1][2].

In Vitro Pyrantel (10 nM-10 µM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity[1][2]. Cell Viability Assay[1] Cell Line: A. suum Concentration: 10 nM-10 µM Incubation Time: 72 h Result: Inhibited A. suum with a pEC50 value of 7.24. Cell Viability Assay[2] Cell Line: N. americanus Concentration: 0-168.2 M (0-100 µg/mL) Incubation Time: 72 h Result: Inhibited third-stage larvae and adult of N. americanus with IC50 values of 2.0 and 7.6 mg/mL, respectively.
In Vivo Pyrantel (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%[2]. Animal Model: Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected)[2]. Dosage: 10 mg/kg Administration: Oral administration; single. Result: Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.
Density 1.13g/cm3
Boiling Point 324.4ºC at 760mmHg
Melting Point 178-179ºC
Molecular Formula C34H30N2O6S
Molecular Weight 594.67700
Flash Point 150ºC
Exact Mass 594.18200
PSA 158.90000
LogP 6.26020
Vapour Pressure 2.13E-17mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UW0248000
CHEMICAL NAME :
Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)-, (E)-
CAS REGISTRY NUMBER :
15686-83-6
LAST UPDATED :
199706
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C11-H14-N2-S
MOLECULAR WEIGHT :
206.33
WISWESSER LINE NOTATION :
T6N CN AUTJ B1U1- BT5SJ& C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANBCB3 Antibiotics and Chemotherapy (Basel). (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.17- 1971- Volume(issue)/page/year: 30,1,1981
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%