100462-37-1

100462-37-1 structure

Name: Rosiridin
Chemical Name: (2R,3R,4S,5S,6R)-2-[(2E)-4-hydroxy-3,7-dimethylocta-2,6-dienoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
CAS Number: 100462-37-1
Molecular Formula: C₁₆H₂₈O₇
Molecular Weight: 332.389
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2018-05-18 08:00:00
Modify Date: 2024-01-03 07:06:06
Rosiridin, which is isolated from Rhodiola rosea L., inhibits MAO A and MAO B with potential beneficial effect in depression and senile dementia. Rosiridin shows an inhibition of 83.8% against MAO B at 10 μM (pIC50=5.38)[1].

Name	(2R,3R,4S,5S,6R)-2-[(2E)-4-hydroxy-3,7-dimethylocta-2,6-dienoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
Synonyms	Rosiridin (2E)-4-Hydroxy-3,7-dimethyl-2,6-octadien-1-yl β-D-glucopyranoside X1221 (2E,4S)-4-Hydroxy-3,7-dimethyl-2,6-octadien-1-yl beta-D-glucopyranoside β-D-Glucopyranoside, (2E)-4-hydroxy-3,7-dimethyl-2,6-octadien-1-yl

Description	Rosiridin, which is isolated from Rhodiola rosea L., inhibits MAO A and MAO B with potential beneficial effect in depression and senile dementia. Rosiridin shows an inhibition of 83.8% against MAO B at 10 μM (pIC50=5.38)[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	pIC50: 5.38 (MAO B)[1]
In Vitro	Rosiridin presents an inhibition 16.2±2.3 and 83.8±1.1% on MAO A and MAO B at a concentration of 10 μM[1].
References	[1]. van Diermen D, et al. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol. 2009 Mar 18;122(2):397-401.

Density	1.3±0.1 g/cm3
Boiling Point	563.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₂₈O₇
Molecular Weight	332.389
Flash Point	294.6±30.1 °C
Exact Mass	332.183502
PSA	119.61000
LogP	-0.11
Vapour Pressure	0.0±3.5 mmHg at 25°C
Index of Refraction	1.555
Storage condition	2-8℃

101409-51-2

~95%

100462-37-1

Literature: Schoettner, Elisabeth; Simon, Kristina; Friedel, Manuel; Jones, Peter G.; Lindel, Thomas Tetrahedron Letters, 2008 , vol. 49, # 39 p. 5580 - 5582

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