51828-97-8
51828-97-8 structure
- Name: MTOB
- Chemical Name: sodium,4-methylsulfanyl-2-oxobutanoate
- CAS Number: 51828-97-8
- Molecular Formula: C5H7NaO3S
- Molecular Weight: 170.16200
- Catalog: Research Areas Cancer
- Create Date: 2018-05-14 08:00:00
- Modify Date: 2024-01-02 13:19:26
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MTOB sodium is a potent C-terminal binding protein (CtBP) inhibitor. MTOB sodium attenuates repetitive head injury-elicited neurologic dysfunction and neuroinflammation via inhibition of the transactivation activity of CtBP1 and CtBP2. MTOB sodium antagonizes the transcriptional regulatory activity of CtBP1 and CtBP2 by eviction from their target promoters in breast cancer cell lines[1][2].
| Name | sodium,4-methylsulfanyl-2-oxobutanoate |
|---|---|
| Synonyms |
KMBA
MFCD00010511 sodium 4-methylsulfanyl-2-oxo-butyrate UNII-2EZY36W75U Sodium 4-(methylthio)-2-oxobutanoate sodium 4-methylthio-2-oxobutyrate Fema No. 3881 4-Methylthio-2-oxobutanoic acid sodium salt |
| Description | MTOB sodium is a potent C-terminal binding protein (CtBP) inhibitor. MTOB sodium attenuates repetitive head injury-elicited neurologic dysfunction and neuroinflammation via inhibition of the transactivation activity of CtBP1 and CtBP2. MTOB sodium antagonizes the transcriptional regulatory activity of CtBP1 and CtBP2 by eviction from their target promoters in breast cancer cell lines[1][2]. |
|---|---|
| Related Catalog | |
| Target |
CtBP[1] |
| In Vitro | MTOB sodium (10 mM) causes significant derepression (P<0.05) of 40% of CtBP target genes (including FGF9, CTNNB1, CEBPB, et al.) in MCF-7 and 46% in MBA-MD-231; increases the pro-epithelial E-cadherin/Vimentin ratio while reducing the pro-mesenchymal CD44/CD24 ratio, with a more significant trend (P<0.05) in MCF-7[2]. |
| In Vivo | MTOB sodium (860 mg/kg; IP, at 1 h and 18 h after the first injury) effectively suppresses the increases duration of righting reflex, and significantly decreased neurological severity score (NSS) scores[1]. Animal Model: C57BL/6 mice (traumatic brain injury)[1] Dosage: 860 mg/kg Administration: IP, at 1 h and 18 h after the first injury Result: Effectively suppressed the increased duration of righting reflex, and significantly decreased NSS scores. |
| References |
| Melting Point | >300ºC(lit.) |
|---|---|
| Molecular Formula | C5H7NaO3S |
| Molecular Weight | 170.16200 |
| Exact Mass | 170.00100 |
| PSA | 82.50000 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | UN 3335 |
| HS Code | 2930909090 |
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |