2922-74-9

2922-74-9 structure

Name: 2'-Deoxyadenosine-5'-monophosphate disodium salt
Chemical Name: 2'-Deoxyadenosine-5'-monophosphate disodium salt
CAS Number: 2922-74-9
Molecular Formula: C₁₀H₁₂N₅Na₂O₆P
Molecular Weight: 375.185
Catalog: Research Areas Metabolic Disease
Create Date: 2018-12-28 10:09:31
Modify Date: 2024-01-05 00:42:28
2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate disodium can be used to study adenosine-based interactions during DNA synthesis and DNA damage[1].

Name	2'-Deoxyadenosine-5'-monophosphate disodium salt
Synonyms	MFCD00065990 disodium 2'-deoxyadenosine 5'-monophosphate 5'-Adenylic acid, 2'-deoxy-, sodium salt (1:2) Disodium 2'-deoxy-5'-O-phosphonatoadenosine EINECS 220-873-3

Description	2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate disodium can be used to study adenosine-based interactions during DNA synthesis and DNA damage[1].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	2′-Deoxyadenosine 5′-monophosphate (dAMP) is incorporated into Caco-2 cells in a time-dependent manner. The uptake of 2′-Deoxyadenosine 5′-monophosphate is increased with a drop in pH, suggesting that 2′-Deoxyadenosine 5′-monophosphate transport activity might be linked to the protons. 2′-Deoxyadenosine 5′-monophosphate uptake by Caco-2 cells is pH- and Na+-dependent[1].
References	[1]. Katsuya Narumi, et al. Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP. PLoS One. 2019 Oct 21;14(10):e0223892. [2]. V Duarte, et al. Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine. Nucleic Acids Res. 1999 Jan 15;27(2):496-502.