20426-12-4

20426-12-4 structure

Name: 4-Hydroxychalcone
Chemical Name: 4-hydroxychalcone
CAS Number: 20426-12-4
Molecular Formula: C₁₅H₁₂O₂
Molecular Weight: 224.25500
Catalog: Chemical reagent Organic reagent Aromatic ketone
Create Date: 2018-04-23 08:00:00
Modify Date: 2024-01-02 10:32:43
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].

Name	4-hydroxychalcone
Synonyms	4-HYDROXYBENZYLIDENEACETOPHENONE 2-(4-Hydroxybenzylidene)acetophenone 2-(4-Hydroxybenzal)acetophenone 4-HYDROXYCHALCONE MFCD00016488 HYDROXYCHALCONE,4 BENZYLIDENE-4-HYDROXYACETOPHENONE

Description	4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology
Target	NF-κB[2]
References	[1]. Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691(1-3):125-33. [2]. Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S37/39-S26
RIDADR	3077.0
RTECS	UD1675000
Hazard Class	9.0
HS Code	2914501900

123-08-0

98-86-2

~97%

20426-12-4

Literature: Rafiee, Ezzat; Rahimi, Farzaneh Journal of the Chilean Chemical Society, 2013 , vol. 58, # 3 p. 1926 - 1929

22252-15-9

~99%

20426-12-4

123-08-0

70-11-1

~53%

20426-12-4

Literature: Lin; Yu; Zhang Synthetic Communications, 1993 , vol. 23, # 3 p. 271 - 276

13735-81-4

123-08-0

~35%

20426-12-4

Literature: Graven, Anette; Grotli, Morten; Meldal, Morten Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 6 p. 955 - 962

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%